Pre-pregnancy metabolic syndrome and insulin administration in gestational diabetes: A nationwide population-based cohort study
- Authors
- Kim, Bo-Yeon; Kim, Bongseong; Han, Kyungdo; Chon, Seung Joo; Yoo, Soon Jib; Kim, Kyoung-Kon
- Issue Date
- Jul-2021
- Publisher
- Elsevier BV
- Keywords
- Gestational diabetes; Insulin; Metabolic syndrome; Obesity
- Citation
- Obesity Research and Clinical Practice, v.15, no.4, pp 362 - 367
- Pages
- 6
- Journal Title
- Obesity Research and Clinical Practice
- Volume
- 15
- Number
- 4
- Start Page
- 362
- End Page
- 367
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18708
- DOI
- 10.1016/j.orcp.2021.06.004
- ISSN
- 1871-403X
1878-0318
- Abstract
- Background: The present study aimed to evaluate whether mothers with obesity/central obesity and metabolic syndrome before gestation are at higher risk of insulin administration in gestational diabetes mellitus (GDM) to diminish the burden of insulin use during pregnancy. Methods: This was a population-based retrospective cohort study conducted using data from the National Health Information Database of Korea. We identified all deliveries from January 1, 2011 to December 31, 2015 (N = 1,214,655). Among the deliveries, we identified mothers with pre-pregnancy health checkup records and without previous diabetes history (N = 325,208). Hazards of insulin use in GDM were calculated based on pre-pregnancy obesity/central obesity and metabolic syndrome. Results: Hazards of insulin use in GDM increased proportionately with an increase in the pre-pregnancy body mass index (BMI) and waist circumference (WC). After the adjustment for clinical factors, high BMI group (>= 30 kg/m(2)) and high WC group (>= 100 cm) were significantly associated with higher hazard ratios (HRs) (HR 4.161, 95% Confidence interval [CI] 3.381-5.121, P < 0.001 and HR 2.563, 95% CI 1.769-3.712, P < 0.001, respectively). The presence of pre-pregnancy metabolic syndrome significantly increased the hazard of insulin use in GDM (0.54% vs. 5.04%). In the presence of obesity (BMI >= 25 kg/m(2)) or central obesity (WC >= 85 cm), HRs of insulin use in GDM were 2.637 (95% CI 2.275-3.056) and 1.603 (95% CI 1.023-2.511), respectively, after adjustment for clinical factors. Conclusions: The presence of pre-pregnancy obesity/central obesity and metabolic syndrome in Korean mothers is associated with increased risk of insulin use in GDM.
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