Bifidobacterium longum subsp. infantis YB0411 Inhibits Adipogenesis in 3T3-L1 Pre-adipocytes and Reduces High-Fat-Diet-Induced Obesity in Mice
DC Field | Value | Language |
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dc.contributor.author | Rahman, Md Shamim | - |
dc.contributor.author | Kang, Inseok | - |
dc.contributor.author | Lee, Youri | - |
dc.contributor.author | Habib, Md Ahasun | - |
dc.contributor.author | Choi, Byeong Jo | - |
dc.contributor.author | Kang, Jong Soon | - |
dc.contributor.author | Park, Doo-Sang | - |
dc.contributor.author | Kim, Yong-Sik | - |
dc.date.accessioned | 2021-09-10T05:46:36Z | - |
dc.date.available | 2021-09-10T05:46:36Z | - |
dc.date.issued | 2021-06-02 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18781 | - |
dc.description.abstract | Although the health benefits of probiotics have been widely known for decades, there has still been limited use of probiotic bacteria in anti-obesity therapy. Herein, we demonstrated the role of Bifidobacterium longum subsp. infantis YB0411 (YB, which was selected by an in vitro adipogenesis assay) in adipogenic differentiation in 3T3-L1 pre-adipocytes. We observed that YB-treatment effectively reduced triglyceride accumulation and the expression of CCAAT/enhancer-binding protein alpha, beta, and delta (C/EBP alpha, C/EBP beta, and C/EBP delta), peroxisome proliferator-activated receptor gamma (PPAR gamma), fatty acid-binding protein 4 (aP2), and acetylCoA carboxylase (ACC). YB-treatment also reduced the levels of core autophagic markers (p62 and LC3B) in 3T3-L1 preadipocytes. Small-interfering-RNA-mediated knockdown and competitive-chemical-inhibition assays showed that AMP-activated protein kinase (AMPK) commenced the anti-adipogenic effect of YB. In addition, YB supplement markedly reduced body weight and fat accretion in mice with high-fat-diet-induced obesity. Our findings suggest that YB may be used as a potential probiotic candidate to ameliorate obesity. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | American Chemical Society | - |
dc.title | Bifidobacterium longum subsp. infantis YB0411 Inhibits Adipogenesis in 3T3-L1 Pre-adipocytes and Reduces High-Fat-Diet-Induced Obesity in Mice | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1021/acs.jafc.1c01440 | - |
dc.identifier.scopusid | 2-s2.0-85107710832 | - |
dc.identifier.wosid | 000659446900026 | - |
dc.identifier.bibliographicCitation | Journal of Agricultural and Food Chemistry, v.69, no.21, pp 6032 - 6042 | - |
dc.citation.title | Journal of Agricultural and Food Chemistry | - |
dc.citation.volume | 69 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 6032 | - |
dc.citation.endPage | 6042 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | LIPID-ACCUMULATION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | ANTIOBESITY | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | AMPK | - |
dc.subject.keywordAuthor | probiotics | - |
dc.subject.keywordAuthor | adipogenesis | - |
dc.subject.keywordAuthor | anti-obesity | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | AMPK | - |
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