Entacapone promotes hippocampal neurogenesis in miceopen access
- Authors
- Yoo, Dae Young; Jung, Hyo Young; Kim, Woosuk; Hahn, Kyu Ri; Kwon, Hyun Jung; Nam, Sung Min; Chung, Jin Young; Yoon, Yeo Sung; Kim, Dae Won; Hwang, In Koo
- Issue Date
- Jun-2021
- Publisher
- Neural Regeneration Research
- Keywords
- brain-derived neurotrophic factor; entacapone; hippocampus; neurogenesis; neurotrophic factor; phosphorylated cAMP response element-binding protein; tyrosine kinase receptor B receptor
- Citation
- Neural Regeneration Research, v.16, no.6, pp 1005 - 1010
- Pages
- 6
- Journal Title
- Neural Regeneration Research
- Volume
- 16
- Number
- 6
- Start Page
- 1005
- End Page
- 1010
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18828
- DOI
- 10.4103/1673-5374.300447
- ISSN
- 1673-5374
1876-7958
- Abstract
- Entacapone, a catechol-O-methyltransferase inhibitor, can strengthen the therapeutic effects of levodopa on the treatment of Parkinson's disease. However, few studies are reported on whether entacapone can affect hippocampal neurogenesis in mice. To investigate the effects of entacapone, a modulator of dopamine, on proliferating cells and immature neurons in the mouse hippocampal dentate gyrus, 60 mice (7 weeks old) were randomly divided into a vehicle-treated group and the groups treated with 10, 50, or 200 mg/kg entacapone. The results showed that 50 and 200 mg/kg entacapone increased the exploration time for novel object recognition. Immunohistochemical staining results revealed that after entacapone treatment, the numbers of Ki67-positive proliferating cells, doublecortin-positive immature neurons, and phosphorylated cAMP response element-binding protein (pCREB)-positive cells were significantly increased. Western blot analysis results revealed that treatment with tyrosine kinase receptor B (TrkB) receptor antagonist significantly decreased the exploration time for novel object recognition and inhibited the expression of phosphorylated TrkB and brain-derived neurotrophic factor (BDNF). Entacapone treatment antagonized the effects of TrkB receptor antagonist. These results suggest that entacapone treatment promoted hippocampal neurogenesis and improved memory function through activating the BDNF-TrkB-pCREB pathway.
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Collections - College of Medicine > Department of Anatomy > 1. Journal Articles
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