Neutrophil-to-Lymphocyte Ratio After Definitive Concurrent Chemoradiotherapy Predicts Survival in Patients With Esophageal Squamous Cell Carcinoma
- Authors
- Koh, Hyeon Kang; Park, Younghee; Koo, Taeryool; Park, Hae Jin; Lee, Me Yeon; Chang, Ah Ram; Hong, Semie; Bae, Hoonsik
- Issue Date
- Mar-2021
- Publisher
- International Institute of Anticancer Research
- Keywords
- Chemoradiotherapy; esophageal squamous cell carcinoma; neutrophil-to-lymphocyte ratio; inflammation
- Citation
- In Vivo, v.35, no.2, pp 1133 - 1139
- Pages
- 7
- Journal Title
- In Vivo
- Volume
- 35
- Number
- 2
- Start Page
- 1133
- End Page
- 1139
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18956
- DOI
- 10.21873/invivo.12359
- ISSN
- 0258-851X
1791-7549
- Abstract
- Background/Aim: Lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio represent systemic immune-inflammatory responses. We evaluated the association between immune-inflammatory cell ratios and prognosis in esophageal squamous cell carcinoma (ESCC) patients who underwent definitive concurrent chemoradiotherapy (dCCRT). Patients and Methods: Medical records of 68 ESCC patients in three institutions who underwent dCCRT between 2006 and 2017 were reviewed. The immune-inflammatory cell ratios were calculated before and after dCCRT. Results: The median follow-up time was 11.4 months. The 3-year overall survival (OS) rate was 21.6%. Among the immune-inflammatory cell ratios, lower post-dCCRT neutrophil-to-lymphocyte ratio (NLRpost) was associated with better OS (median 15.2 vs. 9.7 months, p=0.030). Patients with lower NLRpost had more improved OS when adjuvant chemotherapy was administered following dCCRT (median 16.6 vs. 4.8 months,& nbsp;p<0.001). Conclusion: NLRpost may be useful in predicting OS in ESCC patients after dCCRT. Furthermore, NLRpost might play a role in establishing adjuvant therapy plans following dCCRT.
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Collections - College of Medicine > Department of Radiation Oncology > 1. Journal Articles
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