Comparison of Automated Brain Volume Measures by NeuroQuant vs. Freesurfer in Patients with Mild Cognitive Impairment: Effect of Slice Thicknessopen access
- Authors
- Yim, Younghee; Lee, Ji Young; Oh, Se Won; Chung, Mi Sun; Park, Ji Eun; Moon, Yeonsil; Jeon, Hong Jun; Moon, Won-Jin
- Issue Date
- Mar-2021
- Publisher
- 연세대학교의과대학
- Keywords
- Brain volume; FreeSurfer; mild cognitive impairment; NeuroQuant
- Citation
- Yonsei Medical Journal, v.62, no.3, pp 255 - 261
- Pages
- 7
- Journal Title
- Yonsei Medical Journal
- Volume
- 62
- Number
- 3
- Start Page
- 255
- End Page
- 261
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18972
- DOI
- 10.3349/ymj.2021.62.3255
- ISSN
- 0513-5796
1976-2437
- Abstract
- Purpose: This study aimed to examine the inter-method reliability and volumetric differences between NeuroQuant (NQ) and Freesurfer (FS) using Tl volume imaging sequence with different slice thicknesses in patients with mild cognitive impairment (MCI). Materials and Methods: This retrospective study enrolled 80 patients diagnosed with MCI at our memory clinic. NQ and FS were used for volumetric analysis of three-dimensional Tl -weighted images with slice thickness of 1 and 1.2 mm. Inter-method reliability was measured with Pearson correlation coefficient (r), intraclass correlation coefficient (ICC), and effect size (ES). Results: Overall, NQ volumes were larger than FS volumes in several locations: whole brain (0.78%), cortical gray matter (5.34%), and white matter (2.68%). Volume measures by NQ and FS showed good-to-excellent ICCs with both 1 and 1.2 mm slice thickness (ICC=0.75-0.97, ES=-1.0-0.73 vs. ICC=0.78-0.96, ES=-0.9-0.77, respectively), except for putamen, palfidum, thalamus, and total intracranial volumes. The ICCs in all locations, except the putamen and cerebellum, were slightly higher with a slice thickness of 1 mm compared to those of 1.2 mm. Conclusion: Inter-method reliability between NQ and FS was good-to-excellent in most regions with improvement with a 1-mm slice thickness. This finding indicates that the potential effects of slice thickness should be considered when performing volumetric measurements for cognitive impairment.
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Collections - College of Medicine > Department of Radiology > 1. Journal Articles
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