Increased atrial fibrillation risk in Parkinson's disease: A nationwide population-based studyopen access
- Authors
- Han, Seokmoon; Moon, Inki; Choi, Eue-Keun; Han, Kyung-Do; Cho, Hae-Chan; Lee, Seo-Young; Yang, Seokhun; Kwon, Soonil; Choi, You-jung; Lee, Hyun-Jung; Lee, Euijae; Lee, So-Ryung; Oh, Seil
- Issue Date
- Jan-2021
- Publisher
- John Wiley and Sons Ltd
- Citation
- Annals of Clinical and Translational Neurology, v.8, no.1, pp 238 - 246
- Pages
- 9
- Journal Title
- Annals of Clinical and Translational Neurology
- Volume
- 8
- Number
- 1
- Start Page
- 238
- End Page
- 246
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19029
- DOI
- 10.1002/acn3.51279
- ISSN
- 2328-9503
- Abstract
- Objective: Parkinson's disease (PD) is the second most common neurodegenerative disorder associated with various morbidities. Although the relationship between cardiovascular disease and PD has been studied, a paucity of information on PD and atrial fibrillation (AF) association exists. Thus, we aimed to investigate whether patients with PD have an increased risk of AF. Methods: This study included 57,585 patients with newly diagnosed PD (>= 40-year-old, mean age 69.7 years, men 40.2%) and without a history of AF from the Korean National Health Insurance Service (NHIS) database between 2010 and 2015. Furthermore, an equal number of age- and sex-matched subjects without PD were selected for comparison. The primary outcome was new-onset AF. Results: During the mean follow-up period of 3.4 +/- 1.8 years, AF was newly diagnosed in 3,665 patients. A significantly higher incidence rate of AF was noted among patients with PD than among patients without PD (10.75 and 7.86 per 1000 person-year, respectively). Multivariate Cox-regression analysis revealed that PD was an independent risk factor for AF (hazard ratio [HR]: 1.27, 95% confidence interval [CI]: 1.18-1.36). Furthermore, subgroup analyses revealed that AF risk was higher in the younger age subgroups, and compared with the non-PD group, the youngest PD group (age: 40-49 years) had a threefold increased risk of AF (HR: 3.06, 95% CI: 1.20-7.77). Interpretation: Patients with PD, especially the younger age subgroups, have an increased risk of AF. Active surveillance and management of AF should be considered to prevent further complications.
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