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The 2020 revision of the guidelines for the management of myeloproliferative neoplasmsopen access

Authors
Kim, Sung-YongBae, Sung HwaBang, Soo-MeeEom, Ki-SeongHong, JunshikJang, SeongsooJung, Chul WonKim, Hee-JinKim, Ho YoungKim, Min KyoungKim, Soo-JeongMun, Yeung-ChulNam, Seung-HyunPark, JinnyWon, Jong-HoChoi, Chul Won
Issue Date
Jan-2021
Publisher
대한내과학회
Keywords
Polycythemia vera; Thrombocythemia, essential; Primary myelofibrosis; Practice guideline
Citation
The Korean Journal of Internal Medicine, v.36, no.1, pp 45 - 62
Pages
18
Journal Title
The Korean Journal of Internal Medicine
Volume
36
Number
1
Start Page
45
End Page
62
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19038
DOI
10.3904/kjim.2020.319
ISSN
1226-3303
2005-6648
Abstract
In 2016, the World Health Organization revised the diagnostic criteria for myeloproliferative neoplasms (MPNs) based on the discovery of disease-driving genetic aberrations and extensive analysis of the clinical characteristics of patients with MPNs. Recent studies have suggested that additional somatic mutations have a clinical impact on the prognosis of patients harboring these genetic abnormalities. Treatment strategies have also advanced with the introduction of JAK inhibitors, one of which has been approved for the treatment of patients with myelofibrosis and those with hydroxyurea-resistant or intolerant polycythemia vera. Recently developed drugs aim to elicit hematologic responses, as well as symptomatic and molecular responses, and the response criteria were refined accordingly. Based on these changes, we have revised the guidelines and present the diagnosis, treatment, and risk stratification of MPNs encountered in Korea.
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