Efficacy and Safety of Dual-Drug-Eluting Stents for de Novo Coronary Lesions in South Korea-The Effect Trialopen access
- Authors
- Cha, Jung-Joon; Kim, Gi Chang; Hur, Seung Ho; Bae, Jang Ho; Choi, Jae Woong; Jin, Dong-Kyu; Woo, Seong Il; Lee, Seung Uk; Park, Jong Seon; Cho, Yun-Hyeong; Choi, Cheol Ung; Lim, Do-Sun; Ahn, Tae Hoon
- Issue Date
- Jan-2021
- Publisher
- MDPI AG
- Keywords
- dual drug-eluting stent; Cilotax (TM) stent; DXR (TM) stent; coronary artery disease; clinical outcome
- Citation
- Journal of Clinical Medicine, v.10, no.1, pp 1 - 9
- Pages
- 9
- Journal Title
- Journal of Clinical Medicine
- Volume
- 10
- Number
- 1
- Start Page
- 1
- End Page
- 9
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19042
- DOI
- 10.3390/jcm10010069
- ISSN
- 2077-0383
- Abstract
- Background: Drug-eluting stents (DESs) are commonly used in percutaneous coronary intervention (PCI) procedures; however, complications including in-stent restenosis and stent thrombosis are significant challenges. The dual-DES is a stent that elutes two drugs to target various stages of the restenosis reaction. This study investigated the safety and efficacy of dual-DES in clinical practice. Methods: This study included 375 patients who underwent PCI with Cilotax((TM)) or DXR (TM) dual-DESs at one of 13 centers in South Korea. The primary endpoint was target lesion failure (TLF) within 1 year. The secondary endpoints were cardiac death, myocardial infarction (MI), target lesion revascularization (TLR), and stent thrombosis. Results: The rates of TLF in dual-DESs (3.7%) were comparable to those reported in conventional DES. In addition, the DXR (TM) group had a significantly lower rate of TLF than the Cilotax((TM)) group. In multivariate analysis, the DXR (TM) group had a lower risk of TLF (adjusted hazard ratio (HR) 0.30, 95% CI 0.09-0.92, p = 0.036) and MI (adjusted HR 0.16, 95% CI 0.03-0.82, p = 0.027) than the Cilotax((TM)) group. Conclusion: Dual-DESs had similar clinical outcomes regarding efficacy and safety as conventional DES. Among the dual-DES, the DXR (TM) stent as a new generation dual-DES had more favorable clinical outcomes than the Cilotax((TM)) stent.
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