Extract of Curcuma zedoaria R. prevents atherosclerosis in apolipoprotein E-deficient mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김기모 | - |
dc.contributor.author | 이주영 | - |
dc.contributor.author | 전병화 | - |
dc.contributor.author | Quan Khong Trong | - |
dc.contributor.author | 나민균 | - |
dc.contributor.author | 남궁우 | - |
dc.contributor.author | 채성욱 | - |
dc.date.accessioned | 2021-09-10T06:45:08Z | - |
dc.date.available | 2021-09-10T06:45:08Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 1976-1457 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19322 | - |
dc.description.abstract | BACKGROUND/OBJECTIVES: Curcuma zedoaria R. (Zingiberaceae) has been used to treat headache, fever, and hypertension-related symptoms in Asian countries, including Korea, China, and Japan. We investigated whether dietary intake of a C. zedoaria extract (CzE) affected atherosclerosis in vivo. MATERIALS/METHODS: Apolipoprotein E-deficient (ApoE−/−) mice (n = 32) were fed a normal diet (ND), a high-cholesterol diet (HCD), an HCD containing CzE (100 mg/kg/day), or an HCD containing simvastatin (10 mg/kg/day) for 12 weeks. The anti-atherosclerotic effects were evaluated by observing changes in fatty streak lesions, immunohistochemical analysis, ex vivo fluorescence imaging, lipid profiles, and western blot analysis. RESULTS: The CzE-fed group showed a 41.6% reduction of atherosclerosis. Furthermore, CzE significantly reduced the levels of serum triglyceride, high-density lipoprotein, the chemokine (C-X3-C-motif) ligand 1, the adhesion molecules vascular cell adhesion molecule-1, intracellular adhesion molecule-1, and E-selectin; down-regulation of tumor necrosis factor-α, interleukin-6, high mobility group box-1, and cathepsin levels in the aortic sinuses and aortas of ApoE−/− mice were also observed. CONCLUSIONS: The results suggest that the inclusion of a water extract of C. zedoaria in a HCD is closely correlated with reducing the risk of vascular inflammatory diseases in an ApoE mouse model. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국영양학회 | - |
dc.title | Extract of Curcuma zedoaria R. prevents atherosclerosis in apolipoprotein E-deficient mice | - |
dc.title.alternative | Extract of Curcuma zedoaria R. prevents atherosclerosis in apolipoprotein E-deficient mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 남궁우 | - |
dc.identifier.doi | 10.4162/nrp.2021.15.3.319 | - |
dc.identifier.scopusid | 2-s2.0-85107767758 | - |
dc.identifier.wosid | 000654243100004 | - |
dc.identifier.bibliographicCitation | Nutrition Research and Practice, v.15, no.3, pp.319 - 328 | - |
dc.relation.isPartOf | Nutrition Research and Practice | - |
dc.citation.title | Nutrition Research and Practice | - |
dc.citation.volume | 15 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 319 | - |
dc.citation.endPage | 328 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002717786 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE-CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CATHEPSINS | - |
dc.subject.keywordPlus | RHIZOMES | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordAuthor | Curcuma zedoaria | - |
dc.subject.keywordAuthor | atherosclerosis | - |
dc.subject.keywordAuthor | ApoE knockout mice | - |
dc.subject.keywordAuthor | VCAM-1 | - |
dc.subject.keywordAuthor | chemokine CX3CL1 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.