Extract of Curcuma zedoaria R. prevents atherosclerosis in apolipoprotein E-deficient miceExtract of Curcuma zedoaria R. prevents atherosclerosis in apolipoprotein E-deficient mice
- Other Titles
- Extract of Curcuma zedoaria R. prevents atherosclerosis in apolipoprotein E-deficient mice
- Authors
- 김기모; 이주영; 전병화; Quan Khong Trong; 나민균; 남궁우; 채성욱
- Issue Date
- Jun-2021
- Publisher
- 한국영양학회
- Keywords
- Curcuma zedoaria; atherosclerosis; ApoE knockout mice; VCAM-1; chemokine CX3CL1
- Citation
- Nutrition Research and Practice, v.15, no.3, pp.319 - 328
- Journal Title
- Nutrition Research and Practice
- Volume
- 15
- Number
- 3
- Start Page
- 319
- End Page
- 328
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19322
- DOI
- 10.4162/nrp.2021.15.3.319
- ISSN
- 1976-1457
- Abstract
- BACKGROUND/OBJECTIVES: Curcuma zedoaria R. (Zingiberaceae) has been used to treat headache, fever, and hypertension-related symptoms in Asian countries, including Korea, China, and Japan. We investigated whether dietary intake of a C. zedoaria extract (CzE) affected atherosclerosis in vivo.
MATERIALS/METHODS: Apolipoprotein E-deficient (ApoE−/−) mice (n = 32) were fed a normal diet (ND), a high-cholesterol diet (HCD), an HCD containing CzE (100 mg/kg/day), or an HCD containing simvastatin (10 mg/kg/day) for 12 weeks. The anti-atherosclerotic effects were evaluated by observing changes in fatty streak lesions, immunohistochemical analysis, ex vivo fluorescence imaging, lipid profiles, and western blot analysis.
RESULTS: The CzE-fed group showed a 41.6% reduction of atherosclerosis. Furthermore, CzE significantly reduced the levels of serum triglyceride, high-density lipoprotein, the chemokine (C-X3-C-motif) ligand 1, the adhesion molecules vascular cell adhesion molecule-1, intracellular adhesion molecule-1, and E-selectin; down-regulation of tumor necrosis factor-α, interleukin-6, high mobility group box-1, and cathepsin levels in the aortic sinuses and aortas of ApoE−/− mice were also observed.
CONCLUSIONS: The results suggest that the inclusion of a water extract of C. zedoaria in a HCD is closely correlated with reducing the risk of vascular inflammatory diseases in an ApoE mouse model.
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