Association Between Long-term Functional Outcome and Change in hs-CRP Level in Patients With Acute Ischemic Stroke
- Authors
- Lee, Sujin; Song, In-Uk; Na, Seung-Hee; Jeong, Du-Shin; Chung, Sung-Woo
- Issue Date
- Sep-2020
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Keywords
- high-sensitivity C-reactive protein; functional disability; ischemic stroke; modified Rankin scale
- Citation
- Neurologist, v.25, no.5, pp 122 - 125
- Pages
- 4
- Journal Title
- Neurologist
- Volume
- 25
- Number
- 5
- Start Page
- 122
- End Page
- 125
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19453
- DOI
- 10.1097/NRL.0000000000000278
- ISSN
- 1074-7931
- Abstract
- Background and Purpose: Elevated high-sensitivity C-reactive protein (hs-CRP) has been suggested as a risk factor for ischemic stroke. However, the predictive value of hs-CRP for long-term outcomes is poorly defined. Therefore, we conducted this study to evaluate whether change in hs-CRP level plays a role in the prognostic value of long-term functional disability. Methods: We studied 263 patients with acute ischemic stroke and 104 healthy controls (67.5 +/- 11.26 and 68.17 +/- 11.21 y, respectively). hs-CRP was measured on admission and on the seventh day of hospitalization. The patients were classified into 2 groups on the basis of difference in hs-CRP level from admission to the seventh day of hospitalization (group 1, hs-CRP on admission>the seventh hospital day; group 2, hs-CRP on admission<the seventh hospital day). The correlation between change in hs-CRP level and functional disability using the modified Rankin Scale score (mRS) at 1, 3, 6, and 12 months after stroke onset was analyzed. Results: We observed significant differences between initial hs-CRP level in all patients (0.96 +/- 2.82 mg/dL) and healthy controls (0.34 +/- 0.71 mg/dL,P=0.029). Significant differences in mRS at the 4 different timepoints was not observed between 2 groups (P=0.453, 0.225, 0.229, and 0.396, respectively). The Spearman rank-order correlation coefficients showed that change in hs-CRP level increasingly differed over time and was statistically correlated with mRS (coefficient/P: at 1 mo, 0.139/0.024; at 3 mo, 0.149/0.015; at 6 mo, 0.147/<0.001; and at 12 mo, 0.134/0.03). However, the results were very low correlation coefficients, despite their statistical significance. Conclusion: This study did not clearly show an association between increase in hs-CRP level over time and long-term functional disability.
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