Canonical WNT/beta-Catenin Signaling Activated by WNT9b and RSPO2 Cooperation Regulates Facial Morphogenesis in Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jin, Yong-Ri | - |
dc.contributor.author | Han, Xiang Hua | - |
dc.contributor.author | Nishimori, Katsuhiko | - |
dc.contributor.author | Ben-Avraham, Dan | - |
dc.contributor.author | Oh, Youn Jeong | - |
dc.contributor.author | Shim, Jae-won | - |
dc.contributor.author | Yoon, Jeong Kyo | - |
dc.date.accessioned | 2021-09-10T06:50:18Z | - |
dc.date.available | 2021-09-10T06:50:18Z | - |
dc.date.issued | 2020-05-08 | - |
dc.identifier.issn | 2296-634X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19523 | - |
dc.description.abstract | The R-spondin (RSPO) family of proteins potentiate canonical WNT/beta-catenin signaling and may provide a mechanism to fine-tune the strength of canonical WNT signaling. Although several in vitro studies have clearly demonstrated the potentiation of canonical WNT signaling by RSPOs, whether this potentiation actually occurs in normal development and tissue function in vivo still remains poorly understood. Here, we provide clear evidence of the potentiation of canonical WNT signaling by RSPO during mouse facial development by analyzing compound Wnt9b and Rspo2 gene knockout mice and utilizing ex vivo facial explants. Wnt9b;Rspo2 double mutant mice display facial defects and dysregulated gene expression pattern that are significantly more severe than and different from those of Wnt9b or Rspo2 null mutant mice. Furthermore, we found suggestive evidence that the LGR4/5/6 family of the RSPO receptors may play less critical roles in WNT9b:RSPO2 cooperation. Our results suggest that RSPO-induced cooperation is a key mechanism for fine-tuning canonical WNT/beta-catenin signaling in mouse facial development. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Canonical WNT/beta-Catenin Signaling Activated by WNT9b and RSPO2 Cooperation Regulates Facial Morphogenesis in Mice | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3389/fcell.2020.00264 | - |
dc.identifier.scopusid | 2-s2.0-85085069031 | - |
dc.identifier.wosid | 000536655100001 | - |
dc.identifier.bibliographicCitation | Frontiers in Cell and Developmental Biology, v.8 | - |
dc.citation.title | Frontiers in Cell and Developmental Biology | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Developmental Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Developmental Biology | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | LGR4 | - |
dc.subject.keywordPlus | LIP | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | MUTATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | KIDNEY | - |
dc.subject.keywordPlus | ZNRF3 | - |
dc.subject.keywordAuthor | R-spondin2 | - |
dc.subject.keywordAuthor | Wnt9b | - |
dc.subject.keywordAuthor | WNT signaling | - |
dc.subject.keywordAuthor | facial development | - |
dc.subject.keywordAuthor | cleft lip | - |
dc.subject.keywordAuthor | cleft palate | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.