Factors of Endoscopic Ultrasound-Guided Tissue Acquisition for Successful Next-Generation Sequencing in Pancreatic Ductal Adenocarcinoma
DC Field | Value | Language |
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dc.contributor.author | Park, Jae Keun | - |
dc.contributor.author | Lee, Ji Hyeon | - |
dc.contributor.author | Noh, Dong Hyo | - |
dc.contributor.author | Park, Joo Kyung | - |
dc.contributor.author | Lee, Kyu Taek | - |
dc.contributor.author | Lee, Jong Kyun | - |
dc.contributor.author | Lee, Kwang Hyuck | - |
dc.contributor.author | Jang, Kee-Taek | - |
dc.contributor.author | Cho, Juhee | - |
dc.date.accessioned | 2021-09-10T06:50:25Z | - |
dc.date.available | 2021-09-10T06:50:25Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.issn | 2005-1212 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19531 | - |
dc.description.abstract | Background/Aims: Recent advances in understanding the genetics of pancreatic ductal adenocarcinoma (PDAC) have led to the potential for a personalized approach. Several studies have described the feasibility of generating genetic profiles of PDAC with next-generation sequencing (NGS) of samples obtained through endoscopic ultrasound-guided tissue acquisition (EUS-TA). The aim of this study was to find the best EUS-TA approach for successful NGS of PDAC. Methods: We attempted to perform NGS with tissues from 190 patients with histologically proven PDAC by endoscopic ultrasound-guided fine-needle aspiration and endoscopic ultrasound-guided fine-needle biopsy at Samsung Medical Center between November 2011 and February 2015. The medical records of these patients were retrospectively reviewed for parameters including tumor factors (size, location, and T stage), EUS-TA factors (needle gauge [G], needle type, and number of needle passes) and histologic factors (cellularity and blood contamination). The sample used for NGS was part of the EUS-TA specimen that underwent cytological and histological analysis. Results: NGS could be successfully performed in 109 patients (57.4%). In the univariate analysis, a large needle G (p=0.003) and tumor located in the body/tail (p=0.005) were associated with successful NGS. The multivariate logistic regression analysis revealed that the needle G was an independent factor of successful NGS (odds ratio, 2.19; 95% confidence interval, 1.08 to 4.47: p=0.031). Conclusions: The needle G is an independent factor associated with successful NGS. This finding may suggest that the quantity of cells obtained from EUS-TA specimens is important for successful NGS. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 거트앤리버 발행위원회 | - |
dc.title | Factors of Endoscopic Ultrasound-Guided Tissue Acquisition for Successful Next-Generation Sequencing in Pancreatic Ductal Adenocarcinoma | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5009/gnl19011 | - |
dc.identifier.scopusid | 2-s2.0-85075857150 | - |
dc.identifier.wosid | 000533543100016 | - |
dc.identifier.bibliographicCitation | Gut and Liver, v.14, no.3, pp 387 - 394 | - |
dc.citation.title | Gut and Liver | - |
dc.citation.volume | 14 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 387 | - |
dc.citation.endPage | 394 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002586950 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | FINE-NEEDLE-ASPIRATION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | GEMCITABINE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | FOLFIRINOX | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | Next-generation sequencing | - |
dc.subject.keywordAuthor | Endoscopic ultrasound-guided tissue acquisition | - |
dc.subject.keywordAuthor | Endoscopic ultrasound guided fine-needle aspiration | - |
dc.subject.keywordAuthor | Endoscopic ultrasound guided fine-needle biopsy | - |
dc.subject.keywordAuthor | Pancreatic ductal adenocarcinoma | - |
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