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Fabrication of injectable bone substitute loading porous simvastatin-loaded poly(lactic-co-glycolic acid) microspheres

Authors
Nam Minh-Phuong TranNhi Thao-Ngoc DangNghi Thi-Phuong NguyenLong Vuong-Hoang NguyenTran Ngoc QuyenTran, Phong A.Lee, Byong-TaekNguyen Thi Hiep
Issue Date
12-Apr-2020
Publisher
Taylor & Francis
Keywords
Biphasic calcium phosphate; drug delivery system; injectable bone substitute; poly(lactic-co-glycolic acid) microspheres; simvastatin
Citation
International Journal of Polymeric Materials and Polymeric Biomaterials, v.69, no.6, pp 351 - 362
Pages
12
Journal Title
International Journal of Polymeric Materials and Polymeric Biomaterials
Volume
69
Number
6
Start Page
351
End Page
362
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19539
DOI
10.1080/00914037.2019.1566726
ISSN
0091-4037
1563-535X
Abstract
An injectable bone substitute (IBS) with well-controlled release mechanism of simvastatin (SIM) was fabricated from SIM loaded-porous poly(lactic-co-glycolic acid) microspheres (PLGA MSs), biphasic calcium phosphates (BCP) and CaCO3 nano powder as the solid phase and gelatin, citric acid and hydroxypropyl methylcellulose as the liquid phase. The ratios of PLGA MSs and BCP were varied to obtain IBS with optimal mechanical properties, biocompatibility and bioactivity. In vitro test with MG-63 pre-osteoblast cells showed that IBS with higher amount of PLGA MSs yield better cell adhesion and proliferation. In vivo study on rabbit femoral defect also suggested that the IBS promoted osteogenesis.
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