Comparison of the Efficacy and Safety of Insulin Detemir Administered Once Daily According to Two Titration Algorithms (3-0-3 and 2-4-6-8) in Patients with Type 2 Diabetes Mellitus
DC Field | Value | Language |
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dc.contributor.author | Yu, Hea Min | - |
dc.contributor.author | Park, Kang Seo | - |
dc.contributor.author | Hong, Jun Hwa | - |
dc.contributor.author | Park, Keun Yong | - |
dc.contributor.author | Lee, Jong Min | - |
dc.contributor.author | Ku, Bon Jeong | - |
dc.contributor.author | Kim, Yeo Joo | - |
dc.contributor.author | Oh, Tae Kun | - |
dc.date.accessioned | 2021-09-10T07:24:15Z | - |
dc.date.available | 2021-09-10T07:24:15Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.issn | 2093-5978 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19571 | - |
dc.description.abstract | Background: This study was conducted to compare glycaemic control with insulin detemir administered according to two titration algorithms (3-0-3 and 2-4-6-8) after 20 weeks of treatment in subjects with type 2 diabetes mellitus inadequately controlled on metformin. Methods: This was a 20-week, randomised, multicentre, open-labelled, treat-to-target trial. Forty-six patients were randomised in a 1:1 manner to either the 3-0-3 (G3, n=23) or 2-4-6-8 (G2, n=23) algorithm. The primary endpoint was change of haemoglobin Ale (HbAlc), and the secondary safety endpoint included hypoglycaemic events. Results: After 20 weeks, HbAlc decreased similarly in the G3 and G2 groups, with a mean change of -0.9% from baseline. The mean change in fasting plasma glucose was numerically similar in both groups. The hypoglycaemia event rate per 100-patient-years of exposure (r) in the G2 group (r = 1,427) was higher than that in the G3 group (r = 807). Conclusion: Both treatment groups had numerically similar HbAlc reductions. A trend towards fewer hypoglycaemia episodes after dose stabilisation was seen with the simpler G3. Clinically, this may be an important observation, as a simpler titration algorithm may support self-management and maintenance of insulin therapy. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한내분비학회 | - |
dc.title | Comparison of the Efficacy and Safety of Insulin Detemir Administered Once Daily According to Two Titration Algorithms (3-0-3 and 2-4-6-8) in Patients with Type 2 Diabetes Mellitus | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3803/EnM.2020.35.1.142 | - |
dc.identifier.scopusid | 2-s2.0-85089274125 | - |
dc.identifier.wosid | 000521746900017 | - |
dc.identifier.bibliographicCitation | Endocrinology and Metabolism, v.35, no.1, pp 142 - 148 | - |
dc.citation.title | Endocrinology and Metabolism | - |
dc.citation.volume | 35 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 142 | - |
dc.citation.endPage | 148 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002569602 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | TO-TARGET TRIAL | - |
dc.subject.keywordPlus | NPH INSULIN | - |
dc.subject.keywordPlus | GLYCEMIC CONTROL | - |
dc.subject.keywordPlus | GLUCOSE CONTROL | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | COMPLICATIONS | - |
dc.subject.keywordPlus | INITIATION | - |
dc.subject.keywordPlus | ANALOG | - |
dc.subject.keywordAuthor | Hyperglycemia | - |
dc.subject.keywordAuthor | Insulin | - |
dc.subject.keywordAuthor | Algorithms | - |
dc.subject.keywordAuthor | Diabetes mellitus, type 2 | - |
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