Comparison of the Efficacy and Safety of Insulin Detemir Administered Once Daily According to Two Titration Algorithms (3-0-3 and 2-4-6-8) in Patients with Type 2 Diabetes Mellitusopen access
- Authors
- Yu, Hea Min; Park, Kang Seo; Hong, Jun Hwa; Park, Keun Yong; Lee, Jong Min; Ku, Bon Jeong; Kim, Yeo Joo; Oh, Tae Kun
- Issue Date
- Mar-2020
- Publisher
- 대한내분비학회
- Keywords
- Hyperglycemia; Insulin; Algorithms; Diabetes mellitus, type 2
- Citation
- Endocrinology and Metabolism, v.35, no.1, pp 142 - 148
- Pages
- 7
- Journal Title
- Endocrinology and Metabolism
- Volume
- 35
- Number
- 1
- Start Page
- 142
- End Page
- 148
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19571
- DOI
- 10.3803/EnM.2020.35.1.142
- ISSN
- 2093-596X
2093-5978
- Abstract
- Background: This study was conducted to compare glycaemic control with insulin detemir administered according to two titration algorithms (3-0-3 and 2-4-6-8) after 20 weeks of treatment in subjects with type 2 diabetes mellitus inadequately controlled on metformin. Methods: This was a 20-week, randomised, multicentre, open-labelled, treat-to-target trial. Forty-six patients were randomised in a 1:1 manner to either the 3-0-3 (G3, n=23) or 2-4-6-8 (G2, n=23) algorithm. The primary endpoint was change of haemoglobin Ale (HbAlc), and the secondary safety endpoint included hypoglycaemic events. Results: After 20 weeks, HbAlc decreased similarly in the G3 and G2 groups, with a mean change of -0.9% from baseline. The mean change in fasting plasma glucose was numerically similar in both groups. The hypoglycaemia event rate per 100-patient-years of exposure (r) in the G2 group (r = 1,427) was higher than that in the G3 group (r = 807). Conclusion: Both treatment groups had numerically similar HbAlc reductions. A trend towards fewer hypoglycaemia episodes after dose stabilisation was seen with the simpler G3. Clinically, this may be an important observation, as a simpler titration algorithm may support self-management and maintenance of insulin therapy.
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