A phase II study of etoposide, methylprednisolone, high-dose cytarabine, and oxaliplatin (ESHAOx) for patients with refractory or relapsed Hodgkin's lymphoma
- Authors
- Won, Young-Woong; Lee, Hyewon; Eom, Hyeon-Seok; Kim, Jin Seok; Suh, Cheolwon; Yoon, Dok Hyun; Hong, Jung Yong; Kang, Hye Jin; Lee, Jae Hoon; Kim, Won Seog; Kim, Seok Jin; Lee, Won-Sik; Chang, Myung Hee; Do, Young Rok; Yi, Jun Ho; Kim, Inho; Won, Jong-Ho; Kim, Kyoungha; Oh, Sung Yong; Jo, Jae-Cheol
- Issue Date
- Feb-2020
- Publisher
- Springer Verlag
- Keywords
- Etoposide; Methylprednisolone; Cytarabine; Oxaliplatin; Hodgkin's lymphoma
- Citation
- Annals of Hematology, v.99, no.2, pp 255 - 264
- Pages
- 10
- Journal Title
- Annals of Hematology
- Volume
- 99
- Number
- 2
- Start Page
- 255
- End Page
- 264
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19588
- DOI
- 10.1007/s00277-019-03891-9
- ISSN
- 0939-5555
1432-0584
- Abstract
- We assessed the efficacy and toxicity of etoposide, methylprednisolone, high-dose cytarabine, and oxaliplatin (ESHAOx) combination chemotherapy in patients with refractory or relapsed Hodgkin's lymphoma (HL). This was an open-label, non-randomized, multi-center phase II study. The ESHAOx regimen consisted of intravenous (i.v.) etoposide 40 mg/m(2) on days 1 to 4, i.v. methylprednisolone 500 mg on days 1 to 5, i.v. cytarabine 2 g/m(2) on day 5, and i.v. oxaliplatin 130 mg/m(2) on day 1. Cycles (up to six) were repeated every 3 weeks. In an effort to identify prognostic markers, the serum levels of cytokines including tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and vascular endothelial growth factor (VEGF) were measured at the time of study entry. A total of 37 patients were enrolled, and 36 were available for evaluation of tumor response. The overall response rate was 72.2% (26/36) (complete response, 33.3% [12/36]; partial response, 38.9% [14/36]). The median time to progression was 34.9 months (95% confidence interval, 23.1-46.7 months). The most common grade 3 or 4 hematological adverse events were neutropenia (16/37, 43.2%), followed by thrombocytopenia (10/37, 27.0%). Grade 3 or 4 non-hematological adverse events were nausea (3/37, 8.1%), anorexia (2/37, 5.4%), mucositis (1/37, 2.7%), and skin rash (1/37, 2.7%). There were no treatment-related deaths. High levels of TNF-alpha and CRP were significantly associated with poorer overall survival (p = 0.00005 for TNF-alpha, p = 0.0004 for CRP, respectively). The ESHAOx regimen exhibited antitumor activity and an acceptable safety profile in patients with refractory or relapsed HL.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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