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Early Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein ThrombosisEarly Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein Thrombosis
- Other Titles
- Early Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein Thrombosis
- Issue Date
- 2020
- Publisher
- 대한간암학회
- Keywords
- Oncolytic virus; JX-594; Sorafenib
- Citation
- 대한간암학회지, v.20, no.2, pp 177 - 182
- Pages
- 6
- Journal Title
- 대한간암학회지
- Volume
- 20
- Number
- 2
- Start Page
- 177
- End Page
- 182
- ISSN
- 2288-8128
2383-5001
- Abstract
- JX-594 is a modified oncolytic poxvirus designed to selectively replicate in and destroy cancer cells. In a pilot study, JX-594 injection followed by sorafenib was well-tolerated in three patients and associated with objective tumor responses. In this study, we report a case in which a patient with advanced hepatocellular carcinoma and portal vein thrombosis was treated with a combination of JX-594 and sorafenib.
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Related Researcher
- Lee, Min Hee
- College of Medicine (Department of Radiology)