Microstructures and biological properties of 3D-printed titanium intervertebral spacer with the tri-calcium phosphate loaded demineralized bone matrix hydrogel
- Authors
- Kang, Hoe-Jin; Hossain, Mosharaf; Park, Seong-Su; Im, Soo-Bin; Lee, Byong-Taek
- Issue Date
- 15-Nov-2021
- Publisher
- Elsevier BV
- Keywords
- 3D-printed titanium cage; Intervertebral spacer; Demineralized bone matrix; Tri-calcium phosphate
- Citation
- Materials Letters, v.303, no.0, pp 1 - 4
- Pages
- 4
- Journal Title
- Materials Letters
- Volume
- 303
- Number
- 0
- Start Page
- 1
- End Page
- 4
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19795
- DOI
- 10.1016/j.matlet.2021.130519
- ISSN
- 0167-577X
1873-4979
- Abstract
- The aim of this study was to improve the osteogenic ability of 3D-printed porous titanium (Ti) intervertebral spacer with a Tri-calcium Phosphate (TCP) loaded Demineralized Bone Matrix Hydrogel (DBM). Microstructures and morphologies of Ti, DBM loaded Ti (Ti/DBM), and TCP and DBM loaded Ti (Ti/DBM/TCP) scaffolds were characterized by SEM and EDX. In-vitro studies showed that Ti/DBM/TCP scaffold was biocompatible and could promote osteogenesis by up-regulating the expression of bone-related genes. Furthermore, the results of in-vivo studies using rabbit-femur defect model revealed that the implanted Ti/DBM/TCP scaffold had superior bone regeneration. The TCP and DBM loading were an effective approach of inducing osteogenesis in 3D-printed Ti intervertebral spacer by providing favorable osteogenic differentiation conditions and promoting bone formation.
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Collections - College of Medicine > Department of Regenerative Medicine > 1. Journal Articles
- College of Medicine > Department of Neurosurgery > 1. Journal Articles
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