Antifungal and anti-biofilm effects of 6-shogaol againstCandida auris
DC Field | Value | Language |
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dc.contributor.author | Kim, H. -R. | - |
dc.contributor.author | Eom, Y. -B. | - |
dc.date.accessioned | 2021-08-11T08:26:55Z | - |
dc.date.available | 2021-08-11T08:26:55Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 1364-5072 | - |
dc.identifier.issn | 1365-2672 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/1980 | - |
dc.description.abstract | Aims This study aimed to assess the antifungal and anti-biofilm effects of 6-shogaol againstCandida aurisusingin vitrophenotypic and genotypic analyses. Methods and Results Our results showed that 6-shogaol exhibited antifungal as well as anti-biofilm activity by inhibiting biofilm formation and eradicating the preformed biofilms ofC. auris. The rate and extent of antifungal activity were further confirmed by a time-kill assay. The XTT reduction assay confirmed that 6-shogaol decreased cellular metabolic activity in the biofilm. The effect of 6-shogaol on establishedC. aurisbiofilms was visualized by confocal laser scanning microscopy. Also, this study demonstrated that 6-shogaol reduced the levels of aspartyl proteinases and downregulated the expression of the efflux pump-relatedCDR1gene inC. auris. Conclusions The data indicated that 6-shogaol extracted from ginger had antifungal and anti-biofilm effects onC. auris. Significance and Impact of the Study This study demonstrated the value of the plant-derived 6-shogaol as a promising and potent bioactive compound. The mode of action of this compound againstC. aurisbiofilm was also proposed. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Antifungal and anti-biofilm effects of 6-shogaol againstCandida auris | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/jam.14870 | - |
dc.identifier.scopusid | 2-s2.0-85092390725 | - |
dc.identifier.wosid | 000578732900001 | - |
dc.identifier.bibliographicCitation | Journal of Applied Microbiology, v.130, no.4, pp 1142 - 1153 | - |
dc.citation.title | Journal of Applied Microbiology | - |
dc.citation.volume | 130 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1142 | - |
dc.citation.endPage | 1153 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | CANDIDA-AURIS | - |
dc.subject.keywordPlus | ALBICANS | - |
dc.subject.keywordPlus | GINGER | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | 6-shogaol | - |
dc.subject.keywordAuthor | anti-biofilm | - |
dc.subject.keywordAuthor | antifungal | - |
dc.subject.keywordAuthor | Candida auris | - |
dc.subject.keywordAuthor | efflux pump-relatedCDR1gene | - |
dc.subject.keywordAuthor | secreted aspartyl proteinase | - |
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