Antifungal and anti-biofilm effects of 6-shogaol againstCandida auris
- Authors
- Kim, H. -R.; Eom, Y. -B.
- Issue Date
- Apr-2021
- Publisher
- Blackwell Publishing Inc.
- Keywords
- 6-shogaol; anti-biofilm; antifungal; Candida auris; efflux pump-relatedCDR1gene; secreted aspartyl proteinase
- Citation
- Journal of Applied Microbiology, v.130, no.4, pp 1142 - 1153
- Pages
- 12
- Journal Title
- Journal of Applied Microbiology
- Volume
- 130
- Number
- 4
- Start Page
- 1142
- End Page
- 1153
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/1980
- DOI
- 10.1111/jam.14870
- ISSN
- 1364-5072
1365-2672
- Abstract
- Aims This study aimed to assess the antifungal and anti-biofilm effects of 6-shogaol againstCandida aurisusingin vitrophenotypic and genotypic analyses. Methods and Results Our results showed that 6-shogaol exhibited antifungal as well as anti-biofilm activity by inhibiting biofilm formation and eradicating the preformed biofilms ofC. auris. The rate and extent of antifungal activity were further confirmed by a time-kill assay. The XTT reduction assay confirmed that 6-shogaol decreased cellular metabolic activity in the biofilm. The effect of 6-shogaol on establishedC. aurisbiofilms was visualized by confocal laser scanning microscopy. Also, this study demonstrated that 6-shogaol reduced the levels of aspartyl proteinases and downregulated the expression of the efflux pump-relatedCDR1gene inC. auris. Conclusions The data indicated that 6-shogaol extracted from ginger had antifungal and anti-biofilm effects onC. auris. Significance and Impact of the Study This study demonstrated the value of the plant-derived 6-shogaol as a promising and potent bioactive compound. The mode of action of this compound againstC. aurisbiofilm was also proposed.
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Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
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