Clinical characteristics of non-radiographic axial spondyloarthritis: Results of the Korean Nonradiographic Axial SPondyloArthritis (KONASPA) data
- Authors
- Jeong, Hyemin; Kim, Yong-Gil; Kim, Tae-Hwan; Kim, Tae-Jong; Park, Min-Chan; Seo, Mi Ryoung; Shin, Kichul; Oh, Ji Seon; Lee, Sang-Hoon; Lee, Yeon-Ah; Lee, Eun Young; Baek, Han Joo; Cha, Hoon-Suk
- Issue Date
- Sep-2021
- Publisher
- Blackwell Publishing Inc.
- Keywords
- ankylosing spondylitis; body mass index; disease progression; sacroiliitis; spondyloarthritis
- Citation
- International Journal of Rheumatic Diseases, v.24, no.9, pp 1137 - 1147
- Pages
- 11
- Journal Title
- International Journal of Rheumatic Diseases
- Volume
- 24
- Number
- 9
- Start Page
- 1137
- End Page
- 1147
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19825
- DOI
- 10.1111/1756-185X.14175
- ISSN
- 1756-1841
1756-185X
- Abstract
- Aim To evaluate clinical characteristics and natural history of non-radiographic axial spondyloarthritis (nr-axSpA) using KOrean Nonradiographic Axial SPondyloArthritis (KONASPA) data. Methods Data were collected from 11 centers in South Korea. A total of 278 patients with nr-axSpA from January 2018 to July 2020 were included. Demographic data, clinical features, comorbidities, disease activity, medications, and laboratory results were collected. Results Mean age at symptom onset was 28.2 +/- 14.2 years. Of 278 patients, 152 (54.7%) were male. Mean Bath Ankylosing Spondylitis Disease Activity Index at diagnosis was 3.5 +/- 2.1. Dyslipidemia was the most common comorbidity (8.4%), followed by hypertension (6.1%). Mean age at diagnosis of nr-axSpA was older in female patients than in male patients (31.8 +/- 15.8 years vs 24.9 +/- 12.0 years, P < 0.001). Enthesitis and uveitis were more frequently found in female patients than in male patients. Thirty-one (11.1%) participants with nr-axSpA progressed to ankylosing spondylitis. The median follow-up duration was 48 months. In multivariable Cox regression analysis, age at symptom onset (hazard ratio [HR] 0.93, 95% confidence interval (CI) 0.88-0.97, P = 0.006), body mass index (BMI) (HR 1.24, 95% CI 1.06-1.44, P = 0.005) and sacroiliitis grade (HR 1.86, 95% CI 1.19-2.92, P = 0.006) were associated with progression to ankylosing spondylitis. Conclusions Results of nationwide data revealed that women with nr-axSpA showed a late disease onset and more extra-articular manifestations than men. Young age at symptom onset, high BMI, and presence of radiographic sacroiliitis at diagnosis were risk factors for progression to AS.
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