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Serum Peptide Immunoglobulin G Autoantibody Response in Patients with Different Central Nervous System Inflammatory Demyelinating Disordersopen access

Authors
Lee, Hye LimPark, Jin-WooSeok, Jin MyoungJeon, Mi YoungKim, HojinLim, Young-MinShin, Ha YoungKang, Sa-YoonKwon, Oh-HyunLee, Sang-SooSeok, Hung YoulMin, Ju-HongLee, Sung-HyunKim, Byung-JoKim, Byoung Joon
Issue Date
Aug-2021
Publisher
MDPI AG
Keywords
CNS inflammatory demyelinating disorder; peptide microarray; IgG response
Citation
Diagnostics, v.11, no.8
Journal Title
Diagnostics
Volume
11
Number
8
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19856
DOI
10.3390/diagnostics11081339
ISSN
2075-4418
Abstract
Previous efforts to discover new surrogate markers for the central nervous system (CNS) inflammatory demyelinating disorders have shown inconsistent results; moreover, supporting evidence is scarce. The present study investigated the IgG autoantibody responses to various viral and autoantibodies-related peptides proposed to be related to CNS inflammatory demyelinating disorders using the peptide microarray method. We customized a peptide microarray containing more than 2440 immobilized peptides representing human and viral autoantigens. Using this, we tested the sera of patients with neuromyelitis optica spectrum disorders (NMOSD seropositive, n = 6; NMOSD seronegative, n = 5), multiple sclerosis (MS, n = 5), and myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD, n = 6), as well as healthy controls (HC, n = 5) and compared various peptide immunoglobulin G (IgG) responses between the groups. Among the statistically significant peptides based on the pairwise comparisons of IgG responses in each disease group to HC, cytomegalovirus (CMV)-related peptides were most clearly distinguishable among the study groups. In particular, the most significant differences in IgG response were observed for HC vs. MS and HC vs. seronegative NMOSD (p = 0.064). Relatively higher IgG responses to CMV-related peptides were observed in patients with MS and NMOSD based on analysis of the customized peptide microarray.
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