Association between HbA1C (Glycated Hemoglobin) and Clinical Outcomes in Patients with Subarachnoid Hemorrhage After Neuro-intervention
- Authors
- Park, Chan W.; Yi, Ho J.; Lee, Dong H.; Sung, Jae H.
- Issue Date
- Feb-2021
- Publisher
- Bentham Science Publishers
- Keywords
- Aneurysm; glucose; glycated hemoglobin; hyperglycemia; subarachnoid hemorrhage; HbA1C
- Citation
- Current Neurovascular Research, v.18, no.1, pp 93 - 101
- Pages
- 9
- Journal Title
- Current Neurovascular Research
- Volume
- 18
- Number
- 1
- Start Page
- 93
- End Page
- 101
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19993
- DOI
- 10.2174/1567202618666210225103057
- ISSN
- 1567-2026
1875-5739
- Abstract
- Objective: Our study investigated the association between the level of HbA1c (glycated hemoglobin) at admission and the prognosis of aneurysmal subarachnoid hemorrhage (SAH). Methods: A total of 510 patients treated with neuro-intervention for aneurysmal SAH and with da-ta for admission HbA1c (glycated hemoglobin) were included. Favorable clinical outcome was defined as modified Rankin Scale (mRS) score of 0-2 at 3 months. Receiver operating characteris-tic (ROC) curve analysis was used to identify the optimal cutoff value of HbA1C for unfavorable clinical outcomes. Logistic regression was used to evaluate the association between HbA1C level and outcomes. Results: The optimal cutoff value of HbA1C was identified as 6.0% (P < 0.001), and patients with a high HbA1C (>= 6.0%) had a lower prevalence of favorable clinical outcomes than patients with low HbA1C (< 6.0%) (P < 0.001). High HbA1C (>= 6.0%) was independently associated with unfa-vorable clinical outcome (OR 2.84; 95% CI: 1.52-5.44; P = 0.004). The risk of unfavorable clinical outcome was significantly increased in patients with HbA1C (>= 7.0%, < 8%) and HbA1C (>= 8.0%) compared with lower baseline HbA1C (> 6.0%, < 7%) values (OR 2.17; 95% CI: 1.87-5.13; P = 0.011 and OR 4.25; 95% CI: 3.17-8.41; P = 0.005). Conclusion: Our study showed that HbA1C could be an independent predictor of worse outcomes following neuro-intervention for aneurysmal SAH. High HbA1C (>= 6.0%) was associated with un-favorable clinical outcomes, and gradual elevation of HbA1C contributed to an increase in the risk of worse clinical outcomes after SAH.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Neurosurgery > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19993)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.