Alteration in Cngb1 Expression upon Maternal Immune Activation in a Mouse Model and Its Possible Association with Schizophrenia Susceptibility
- Authors
- Lee, Hwayoung; Kang, Sung Wook; Jeong, Hyeonjung; Kwon, Jun-Tack; Kim, Young Ock; Kim, Hak-Jae
- Issue Date
- Nov-2021
- Publisher
- 대한정신약물학회
- Keywords
- Cyclic nucleotide-gated channel subunit beta 1; Single nucleotide polymorphism; Maternal immune acti-vation; Animal model; Schizophrenia
- Citation
- Clinical Psychopharmacology and Neuroscience, v.19, no.4, pp 618 - 627
- Pages
- 10
- Journal Title
- Clinical Psychopharmacology and Neuroscience
- Volume
- 19
- Number
- 4
- Start Page
- 618
- End Page
- 627
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20119
- DOI
- 10.9758/cpn.2021.19.4.618
- ISSN
- 1738-1088
2093-4327
- Abstract
- Objective: The cyclic nucleotide-gated channel (Cng) regulates synaptic efficacy in brain neurons by modulating Ca2+ levels in response to changes in cyclic nucleotide concentrations. This study investigated whether the expression of Cng channel, cyclic nucleotide-gated channel subunit beta 1 (Cngb1) exhibited any relationship with the pathophysiol-ogy of schizophrenia in an animal model and whether genetic polymorphisms of the human gene were associated with the progression of schizophrenia in a Korean population. Methods: We investigated whether Cngb1 expression was related to psychiatric disorders in a mouse model of schizo-phrenia induced by maternal immune activation. A case-control study was conducted of 275 schizophrenia patients and 410 controls with single-nucleotide polymorphisms (SNPs) in the 5 '-near region of CNGB1. Results: Cngb1 expression was decreased in the prefrontal cortex in the mouse model. Furthermore, the genotype fre-quency of a SNP (rs3756314) of CNGB1 was associated with the risk of schizophrenia. Conclusion: Our results suggest that CNGB1 might be associated with schizophrenia susceptibility and maternal immune activation. Consequently, it is hypothesized that CNGB1 may be involved in the pathophysiology of schizophrenia.
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Collections - College of Medicine > Department of Clinical Pharmacology > 1. Journal Articles
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