Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis
DC Field | Value | Language |
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dc.contributor.author | Whalen, William | - |
dc.contributor.author | Buyukozkan, Mustafa | - |
dc.contributor.author | Moore, Bethany | - |
dc.contributor.author | Moon, Jong-Seok | - |
dc.contributor.author | Dela Cruz, Charles S. | - |
dc.contributor.author | Martinez, Fernando J. | - |
dc.contributor.author | Choi, Augustine M. K. | - |
dc.contributor.author | Krumsiek, Jan | - |
dc.contributor.author | Stout-Delgado, Heather | - |
dc.contributor.author | Cho, Soo Jung | - |
dc.date.accessioned | 2022-02-07T01:40:38Z | - |
dc.date.available | 2022-02-07T01:40:38Z | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 0040-6376 | - |
dc.identifier.issn | 1468-3296 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20328 | - |
dc.description.abstract | Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with unclear aetiology and poorly understood pathophysiology. Although plasma levels of circulating cell-free DNA (ccf-DNA) and metabolomic changes have been reported in IPF, the associations between ccf-DNA levels and metabolic derangements in lung fibrosis are unclear. Here, we demonstrate that ccf-double-stranded DNA (dsDNA) is increased in patients with IPF with rapid progression of disease compared with slow progressors and healthy controls and that ccf-dsDNA associates with amino acid metabolism, energy metabolism and lipid metabolism pathways in patients with IPF. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BMJ Publishing Group | - |
dc.title | Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1136/thoraxjnl-2021-217315 | - |
dc.identifier.scopusid | 2-s2.0-85123649815 | - |
dc.identifier.wosid | 000721907300001 | - |
dc.identifier.bibliographicCitation | Thorax, v.77, no.2, pp 186 - 190 | - |
dc.citation.title | Thorax | - |
dc.citation.volume | 77 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 186 | - |
dc.citation.endPage | 190 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | GLYCOLYSIS | - |
dc.subject.keywordAuthor | idiopathic pulmonary fibrosis | - |
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