Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis
- Authors
- Whalen, William; Buyukozkan, Mustafa; Moore, Bethany; Moon, Jong-Seok; Dela Cruz, Charles S.; Martinez, Fernando J.; Choi, Augustine M. K.; Krumsiek, Jan; Stout-Delgado, Heather; Cho, Soo Jung
- Issue Date
- Feb-2022
- Publisher
- BMJ Publishing Group
- Keywords
- idiopathic pulmonary fibrosis
- Citation
- Thorax, v.77, no.2, pp 186 - 190
- Pages
- 5
- Journal Title
- Thorax
- Volume
- 77
- Number
- 2
- Start Page
- 186
- End Page
- 190
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20328
- DOI
- 10.1136/thoraxjnl-2021-217315
- ISSN
- 0040-6376
1468-3296
- Abstract
- Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with unclear aetiology and poorly understood pathophysiology. Although plasma levels of circulating cell-free DNA (ccf-DNA) and metabolomic changes have been reported in IPF, the associations between ccf-DNA levels and metabolic derangements in lung fibrosis are unclear. Here, we demonstrate that ccf-double-stranded DNA (dsDNA) is increased in patients with IPF with rapid progression of disease compared with slow progressors and healthy controls and that ccf-dsDNA associates with amino acid metabolism, energy metabolism and lipid metabolism pathways in patients with IPF.
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- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Integrated Biomedical Science > 1. Journal Articles
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