Scoring model for discriminating gastric cancer risk in patients with negative serum pepsinogen and anti-Helicobacter pylori antibody results
DC Field | Value | Language |
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dc.contributor.author | Cho, Jun-Hyung | - |
dc.contributor.author | Jin, So-Young | - |
dc.contributor.author | Park, Suyeon | - |
dc.date.accessioned | 2022-02-22T01:40:36Z | - |
dc.date.available | 2022-02-22T01:40:36Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.issn | 1440-1746 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20421 | - |
dc.description.abstract | Background The ABC test measures serum pepsinogen and anti-Helicobacter pylori IgG antibody levels to predict precancerous conditions in the stomach and gastric cancer. However, a limitation of this test is that the gastric cancer risk is not negligible in patients with a negative result. Methods Based on their ABC results, 1157 patients were classified into Groups A (n = 392), B (n = 479), C (n = 247), and D (n = 39). In Group A, 24.2% of patients had atrophic gastritis and/or intestinal metaplasia and had thus been incorrectly assigned to Group A. Patients in Group A were then assigned to derivation (n = 236) and validation (n = 156) cohorts by 3:2 random sampling. Logistic regression analyses were performed to identify the factors discriminating between a correct (true) and incorrect (false) Group A classification. Results A 4-point discriminative model was constructed based on a high-negative H. pylori IgG antibody titer and the patient's age (50-64 and >= 65 years). The areas under the receiver operating characteristic curve for the derivation and validation cohorts were 0.868 and 0.894, respectively. In the validation cohort, the addition of a discriminative model score >= 2 to the ABC method showed a similar accuracy for predicting gastric cancer risk compared with the ABC method alone (93.8% vs. 92.4%). Conclusion The 4-point discriminative model may help identify patients with a normal serological test who are nonetheless at risk of developing gastric cancer. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Scoring model for discriminating gastric cancer risk in patients with negative serum pepsinogen and anti-Helicobacter pylori antibody results | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/jgh.15630 | - |
dc.identifier.scopusid | 2-s2.0-85111536314 | - |
dc.identifier.wosid | 000679471500001 | - |
dc.identifier.bibliographicCitation | Journal of Gastroenterology and Hepatology, v.36, no.12, pp 3345 - 3353 | - |
dc.citation.title | Journal of Gastroenterology and Hepatology | - |
dc.citation.volume | 36 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3345 | - |
dc.citation.endPage | 3353 | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | TERM-FOLLOW-UP | - |
dc.subject.keywordPlus | IGG ANTIBODY | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | ERADICATION | - |
dc.subject.keywordPlus | LIMITATIONS | - |
dc.subject.keywordPlus | METAPLASIA | - |
dc.subject.keywordPlus | ENDOSCOPY | - |
dc.subject.keywordPlus | SEROLOGY | - |
dc.subject.keywordAuthor | ABC method | - |
dc.subject.keywordAuthor | Helicobacter pylori | - |
dc.subject.keywordAuthor | model | - |
dc.subject.keywordAuthor | pepsinogen | - |
dc.subject.keywordAuthor | score | - |
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