Scoring model for discriminating gastric cancer risk in patients with negative serum pepsinogen and anti-Helicobacter pylori antibody results
- Authors
- Cho, Jun-Hyung; Jin, So-Young; Park, Suyeon
- Issue Date
- Dec-2021
- Publisher
- Blackwell Publishing Inc.
- Keywords
- ABC method; Helicobacter pylori; model; pepsinogen; score
- Citation
- Journal of Gastroenterology and Hepatology, v.36, no.12, pp 3345 - 3353
- Pages
- 9
- Journal Title
- Journal of Gastroenterology and Hepatology
- Volume
- 36
- Number
- 12
- Start Page
- 3345
- End Page
- 3353
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20421
- DOI
- 10.1111/jgh.15630
- ISSN
- 0815-9319
1440-1746
- Abstract
- Background The ABC test measures serum pepsinogen and anti-Helicobacter pylori IgG antibody levels to predict precancerous conditions in the stomach and gastric cancer. However, a limitation of this test is that the gastric cancer risk is not negligible in patients with a negative result. Methods Based on their ABC results, 1157 patients were classified into Groups A (n = 392), B (n = 479), C (n = 247), and D (n = 39). In Group A, 24.2% of patients had atrophic gastritis and/or intestinal metaplasia and had thus been incorrectly assigned to Group A. Patients in Group A were then assigned to derivation (n = 236) and validation (n = 156) cohorts by 3:2 random sampling. Logistic regression analyses were performed to identify the factors discriminating between a correct (true) and incorrect (false) Group A classification. Results A 4-point discriminative model was constructed based on a high-negative H. pylori IgG antibody titer and the patient's age (50-64 and >= 65 years). The areas under the receiver operating characteristic curve for the derivation and validation cohorts were 0.868 and 0.894, respectively. In the validation cohort, the addition of a discriminative model score >= 2 to the ABC method showed a similar accuracy for predicting gastric cancer risk compared with the ABC method alone (93.8% vs. 92.4%). Conclusion The 4-point discriminative model may help identify patients with a normal serological test who are nonetheless at risk of developing gastric cancer.
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Collections - College of Medicine > Department of Pathology > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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