Two-dimensional shear wave elastography for assessing liver fibrosis in patients with chronic liver disease: a prospective cohort studyopen access
- Authors
- Yoo, Hae Won; Kim, Sang Gyune; Jang, Jae Young; Yoo, Jeong-Ju; Jeong, Soung Won; Kim, Young Seok; Kim, Boo Sung
- Issue Date
- Mar-2022
- Publisher
- 대한내과학회
- Keywords
- Elasticity imaging techniques; Liver cirrhosis; ROC curve
- Citation
- The Korean Journal of Internal Medicine, v.37, no.2, pp 285 - 293
- Pages
- 9
- Journal Title
- The Korean Journal of Internal Medicine
- Volume
- 37
- Number
- 2
- Start Page
- 285
- End Page
- 293
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20570
- DOI
- 10.3904/kjim.2020.635
- ISSN
- 1226-3303
2005-6648
- Abstract
- Background/Aims: The objective of this study was to determine whether the newly developed two-dimensional shear wave elastography (2D-SWE, RS85, Samsung-shearwave imaging) was more valid and reliable than transient elastography (TE) for predicting the stage of liver fibrosis. Methods: The study prospectively enrolled a total of 116 patients with chronic liver disease who underwent 2D-SWE, TE, laboratory testing, and liver biopsy on the same day from two tertiary care hospitals. One patient with unreliable measurement was excluded. The measurement of 2D-SWE was considered acceptable when a homogenous color pattern in a region of interest of at least 10 mm was detected at 10 different sites. Diagnostic performance was calculated using area under the receiver operating characteristic Results: Liver fibrosis stages included F0 (18%), F1 (19%), F2 (24%), F3 (22%), and F4 (17%). Interclass correlation coefficient for inter-observer agreement in 2D-SWE was 0.994 (95% confidence interval [CI], 0.988 to 0.997). Overall, the results of 2D-SWE and stages of histological fibrosis were significantly correlated (r = 0.601, p < 0.001). For The 2D-SWE showed good diagnostic ability (AUROC, 0.851; 95% CI, 0.773 to 0.911) comparable to TE (AUROC, 0.859; 95% CI, 0.781 to 0.916) for the diagnosis of significant fibrosis (>= F2), and the cut-off value was 5.8 kPa. AUROC and optimal cut-off of 2D-SWE for the diagnosis of liver cirrhosis were 0.889 (95% CI, 0.817 to 0.940) and 9.6 kPa, respectively. TE showed similar diagnostic performance in distinguishing cirrhosis (AUROC, 0.938; 95% CI, 0.877 to 0.974; p = 0.08). Conclusions: 2D-SWE is comparable to TE in diagnosing significant fibrosis and liver cirrhosis with high reliability.
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