Recent patents in allergy and immunology: A quantitative real-time polymerase chain reaction method for diagnosing asthma and asthma exacerbationopen access
- Authors
- Lee, Pureun-Haneul; Choi, SeonMuk; An, MinHyeok; Jang, An-Soo
- Issue Date
- 1-Apr-2022
- Publisher
- BioMed Central
- Keywords
- asthma; diagnosis; nectin-4; qRT-PCR
- Citation
- Clinical and Translational Allergy, v.12, no.4, pp 1 - 3
- Pages
- 3
- Journal Title
- Clinical and Translational Allergy
- Volume
- 12
- Number
- 4
- Start Page
- 1
- End Page
- 3
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20655
- DOI
- 10.1002/clt2.12136
- ISSN
- 2045-7022
- Abstract
- Background: Asthma is diagnosed based on a history of the characteristic symptoms and evidence of expiratory airflow limitation. However, asthma diagnosis using the existing tests is associated with a risk of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 spread. In this study, we developed a quantitative real-time polymerase chain reaction (qRT-PCR)-based asthma diagnosis tool. Methods: We detected nectin-4 in the plasma of patients with asthma using qRT-PCR, explored the relationship of clinical variables. Results: quantitative real-time polymerase chain reaction revealed that plasma nectin-4 mRNA levels were higher in asthmatics than controls. These results correlated with lung function. Conclusions: Those results suggest that qRT-PCR for nectin-4 may aid asthma diagnosis and monitoring.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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