Clinical Implication of Hypoxic Liver Injury for Predicting Hypoxic Hepatitis and In-Hospital Mortality in ST Elevation Myocardial Infarction Patients
DC Field | Value | Language |
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dc.contributor.author | Choi, Seong Huan | - |
dc.contributor.author | Jang, Ho-Jun | - |
dc.contributor.author | Suh, Young Ju | - |
dc.contributor.author | Park, Sang-Don | - |
dc.contributor.author | Oh, Pyung Chun | - |
dc.contributor.author | Moon, Jeonggeun | - |
dc.contributor.author | Lee, Kyounghoon | - |
dc.contributor.author | Suh, Jon | - |
dc.contributor.author | Kang, WoongChol | - |
dc.contributor.author | Kim, Tae-Hoon | - |
dc.contributor.author | Kwon, Sung Woo | - |
dc.date.accessioned | 2022-05-30T06:40:18Z | - |
dc.date.available | 2022-05-30T06:40:18Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.issn | 1976-2437 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20847 | - |
dc.description.abstract | Purpose: In this study, we aimed to determine the value of hypoxic liver injury (HLI) in the emergency room (ER) for predicting hypoxic hepatitis (HH) and in-hospital mortality in ST elevation myocardial infarction (STEMI) patients. Materials and Methods: 1537 consecutive STEMI patients were enrolled. HLI in the ER was defined as a >= 2-fold increase in serum aspartate transaminase (AST). HH was defined as a >= 20-fold increase in peak serum transaminase. Patients were divided into four groups according to HLI and HH status (group 1, no HLI or HH; group 2, HLI, but no HH; group 3, no HLI, but HH; group 4, both HLI and HH). Results: The incidences of HLI and HH in the ER were 22% and 2%, respectively. In-hospital mortality rates were 3.1%, 11.8%, 28.6%, and 47.1% for groups 1, 2, 3, and 4, respectively. Patients with HLI and/or HH had worse Killip class, higher cardiac biomarker elevations, and lower left ventricular ejection fraction. Multivariate logistic regression analysis showed that HLI in the ER was an independent predictor of HH [odds ratio 2.572, 95% confidence interval (CI) 1.166-5.675, p=0.019]. The predictive value of HLI in the ER for the development of HH during hospitalization was favorable [area under the curve (AUC) 0.737, 95% CI 0.643-0.830, sensitivity 0.548, specificity 0.805, for cut-off value AST >80]. Furthermore, in terms of in-hospital mortality, predictive values of HLI in the ER and HH during hospitalization were comparable (AUC 0.701 for HLI at ER and AUC 0.674 for HH). Conclusion: Among STEMI patients, HLI in the ER is a significant predictor for the development of HH and mortality during hospitalization (INTERSTELLAR ClinicalTrials.gov number, NCT02800421). | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 연세대학교의과대학 | - |
dc.title | Clinical Implication of Hypoxic Liver Injury for Predicting Hypoxic Hepatitis and In-Hospital Mortality in ST Elevation Myocardial Infarction Patients | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3349/ymj.2021.62.10.877 | - |
dc.identifier.wosid | 000701782500002 | - |
dc.identifier.bibliographicCitation | Yonsei Medical Journal, v.62, no.10, pp 877 - 884 | - |
dc.citation.title | Yonsei Medical Journal | - |
dc.citation.volume | 62 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 877 | - |
dc.citation.endPage | 884 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002755823 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject.keywordPlus | CARE-UNIT | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | HEPATOPATHY | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordPlus | TRENDS | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordAuthor | STEMI | - |
dc.subject.keywordAuthor | hypoxic liver injury | - |
dc.subject.keywordAuthor | hypoxic hepatitis | - |
dc.subject.keywordAuthor | in-hospital mortality | - |
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