Clinical Implication of Hypoxic Liver Injury for Predicting Hypoxic Hepatitis and In-Hospital Mortality in ST Elevation Myocardial Infarction Patientsopen access
- Authors
- Choi, Seong Huan; Jang, Ho-Jun; Suh, Young Ju; Park, Sang-Don; Oh, Pyung Chun; Moon, Jeonggeun; Lee, Kyounghoon; Suh, Jon; Kang, WoongChol; Kim, Tae-Hoon; Kwon, Sung Woo
- Issue Date
- Oct-2021
- Publisher
- 연세대학교의과대학
- Keywords
- STEMI; hypoxic liver injury; hypoxic hepatitis; in-hospital mortality
- Citation
- Yonsei Medical Journal, v.62, no.10, pp 877 - 884
- Pages
- 8
- Journal Title
- Yonsei Medical Journal
- Volume
- 62
- Number
- 10
- Start Page
- 877
- End Page
- 884
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20847
- DOI
- 10.3349/ymj.2021.62.10.877
- ISSN
- 0513-5796
1976-2437
- Abstract
- Purpose: In this study, we aimed to determine the value of hypoxic liver injury (HLI) in the emergency room (ER) for predicting hypoxic hepatitis (HH) and in-hospital mortality in ST elevation myocardial infarction (STEMI) patients. Materials and Methods: 1537 consecutive STEMI patients were enrolled. HLI in the ER was defined as a >= 2-fold increase in serum aspartate transaminase (AST). HH was defined as a >= 20-fold increase in peak serum transaminase. Patients were divided into four groups according to HLI and HH status (group 1, no HLI or HH; group 2, HLI, but no HH; group 3, no HLI, but HH; group 4, both HLI and HH). Results: The incidences of HLI and HH in the ER were 22% and 2%, respectively. In-hospital mortality rates were 3.1%, 11.8%, 28.6%, and 47.1% for groups 1, 2, 3, and 4, respectively. Patients with HLI and/or HH had worse Killip class, higher cardiac biomarker elevations, and lower left ventricular ejection fraction. Multivariate logistic regression analysis showed that HLI in the ER was an independent predictor of HH [odds ratio 2.572, 95% confidence interval (CI) 1.166-5.675, p=0.019]. The predictive value of HLI in the ER for the development of HH during hospitalization was favorable [area under the curve (AUC) 0.737, 95% CI 0.643-0.830, sensitivity 0.548, specificity 0.805, for cut-off value AST >80]. Furthermore, in terms of in-hospital mortality, predictive values of HLI in the ER and HH during hospitalization were comparable (AUC 0.701 for HLI at ER and AUC 0.674 for HH). Conclusion: Among STEMI patients, HLI in the ER is a significant predictor for the development of HH and mortality during hospitalization (INTERSTELLAR ClinicalTrials.gov number, NCT02800421).
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