Effect of Angiogenesis and Lymphangiogenesis in Diesel Exhaust Particles Inhalation in Mouse Model of LPS Induced Acute Otitis Media
DC Field | Value | Language |
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dc.contributor.author | Kim, Byeong-Gon | - |
dc.contributor.author | Choi, Da Yeon | - |
dc.contributor.author | Kim, Min-Gyoung | - |
dc.contributor.author | Jang, An-Soo | - |
dc.contributor.author | Suh, Myung-Whan | - |
dc.contributor.author | Lee, Jun Ho | - |
dc.contributor.author | Oh, Seung Ha | - |
dc.contributor.author | Park, Moo Kyun | - |
dc.date.accessioned | 2022-06-14T02:50:12Z | - |
dc.date.available | 2022-06-14T02:50:12Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 2235-2988 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21040 | - |
dc.description.abstract | Lymphangiogenesis and angiogenesis might have significant involvement in the pathogenesis of otitis media with effusion. This study investigated the effect of diesel exhaust particles (DEP) on inflammation and lymphangiogenesis in a mouse model of acute otitis media (AOM). BALB/c mice were injected with LPS and exposed to 100 mu g/m(3) DEP. The mice were divided into four groups: control (no stimulation), AOM, AOM + DEP, and DEP + AOM.The effects of DEP inhalation pre- and post-DEP induction were estimated based on measurements of the auditory brainstem response, mRNA levels of lymphangiogenesis-related genes and cytokines, and histology of the middle ear. Cell viability of human middle ear epithelial cells decreased in a dose-response manner at 24 and 48 hours post-DEP exposure. DEP alone did not induce AOM. AOM-induced mice with pre- or post-DEP exposure showed thickened middle ear mucosa and increased expression of TNF-alpha and IL1-beta mRNA levels compared to the control group, but increased serum IL-1 beta levels were not found in the AOM + Post DEP. The mRNA expression of TLR4, VEGFA, VEGFAC, and VEGFR3 was increased by pre-AOM DEP exposure.The expression of VEFGA protein was stronger in the AOM + Post DEP group than in any other group. The expression of CD31 and CD45 markers in the mouse middle ear tissue was higher in the Pre DEP + AOM group than in the AOM group. This result implies that pre-exposure to DEP more strongly increases inflammation and lymphangiogenesis in a mouse model of acute otitis media. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Effect of Angiogenesis and Lymphangiogenesis in Diesel Exhaust Particles Inhalation in Mouse Model of LPS Induced Acute Otitis Media | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3389/fcimb.2022.824575 | - |
dc.identifier.scopusid | 2-s2.0-85130978392 | - |
dc.identifier.wosid | 000804007300001 | - |
dc.identifier.bibliographicCitation | Frontiers in cellular and infection microbiology, v.12, no.0, pp 1 - 12 | - |
dc.citation.title | Frontiers in cellular and infection microbiology | - |
dc.citation.volume | 12 | - |
dc.citation.number | 0 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | MIDDLE-EAR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | diesel exhaust particles | - |
dc.subject.keywordAuthor | lipopolysaccharides | - |
dc.subject.keywordAuthor | otitis media | - |
dc.subject.keywordAuthor | lymphangiogenesis | - |
dc.subject.keywordAuthor | angiogenesis | - |
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