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A self-pressure-driven blood plasma-separation device for point-of-care diagnostics

Authors
Kim, HanbiPark, HyeonseekChung, Doo RyeonKim, TaekyungPark, EunkyoungKang, Minhee
Issue Date
Sep-2022
Publisher
Elsevier BV
Keywords
Point-of-care diagnostics; Blood plasma-separation; Rapid diagnostic test kit; Lateral flow assay; Infectious disease; Serology
Citation
Talanta, v.247, no.0, pp 1 - 8
Pages
8
Journal Title
Talanta
Volume
247
Number
0
Start Page
1
End Page
8
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21158
DOI
10.1016/j.talanta.2022.123562
ISSN
0039-9140
1873-3573
Abstract
We aimed to develop a portable, simple-to-use, and self-pressure-driven blood plasma-separation device that can be combined with rapid diagnostic test kits. This simple, disposable, and electrical equipment-free apparatus has been designed to separate plasma from a few microliters of blood with only hand-powered operation. The refined plasma sample is then delivered to multiple lateral flow assay kits directly connected to the device for the detection of various serological markers. The required time for all steps was just 1 min. We validated the device through multifaceted experiments. The developed multifunctional device enables to perform all blood test steps of diagnostic medical examination at the point-of-care.
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College of Medical Sciences > Department of Biomedical Mechatronics > 1. Journal Articles

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