Three-dimensional analysis of injury conditions of single muscle fibers in small animals using phase-contrast X-ray imaging
- Authors
- Lee, Jiwon; Jang, Sang-Hun; Lee, Onseok
- Issue Date
- Jan-2021
- Publisher
- John Wiley & Sons Inc.
- Keywords
- 3D; mouse; phase-contrast X-ray; single muscle fiber; synchrotron; volume rendering
- Citation
- Microscopy Research and Technique, v.84, no.1, pp 38 - 41
- Pages
- 4
- Journal Title
- Microscopy Research and Technique
- Volume
- 84
- Number
- 1
- Start Page
- 38
- End Page
- 41
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2132
- DOI
- 10.1002/jemt.23561
- ISSN
- 1059-910X
1097-0029
- Abstract
- Muscle damage can reduces the biological functions and lead to ultimately a disease state. For the reason, it is important to accurately check the state of an injury such as atrophy, and it is required to identify the state of fibers constituting the muscle. This study describes a novel method of analyzing single muscle fibers with injury conditions in three-dimensions. The muscle fibers of the mice were visualized using phase-contrast X-ray projection the microstructure. In additions, it was possible to confirm the status by quantitatively analyzing the injury severity of muscle fibers. Significantly, the muscle conditions of multiple individuals were individually determined. This study could contributes to areas where it is very important to identify microdetailed and quantitative changes of state, such as new drug development.
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Collections - College of Medical Sciences > Department of Medical IT Engineering > 1. Journal Articles
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