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Change of mortality of patients with acute ischemic stroke before and after 2015open access

Authors
Park, Sang-WonLee, Ji YoungHeo, Nam HunHan, James JisuLee, Eun ChaeHong, Dong-YongLee, Dong-HunLee, Byung CheolLim, Young WhaKim, Gui OkLee, Man RyulOh, Jae Sang
Issue Date
Aug-2022
Publisher
Frontiers Media S.A.
Keywords
stroke; acute ischemic stroke; mechanical thrombectomy (MT); intravenous thrombolysis (IVT); trend research; stroke care
Citation
Frontiers in Neurology, v.13, no.0, pp 1 - 13
Pages
13
Journal Title
Frontiers in Neurology
Volume
13
Number
0
Start Page
1
End Page
13
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21428
DOI
10.3389/fneur.2022.947992
ISSN
1664-2295
Abstract
IntroductionAdvances in the diagnosis and management of acute ischemic stroke (AIS) and the increased use of mechanical thrombectomy (MT) have improved the quality of care and prognosis of patients with AIS since 2015. We investigated the changing trends in mortality of patients with AIS in Korea before and after 2015. Materials and methodsA retrospective cohort study was conducted using combined anonymized data from the Acute Stroke Assessment Registry of Korea and the Health Insurance Review & Assessment Service database. Patients with ischemic stroke with precise onset time and initial National Institute of Health Stroke Scale records were included. ResultsPatients receiving MT treatment increased from 256 (2.7%) pre-2015 to 1,037 (3.9%) post-2015 (p < 0.001). Overall mortality significantly decreased from pre-2015 to post-2015. In pre-2015, intravenous thrombolysis (IVT) administered within 2 h significantly reduced 3-month mortality when compared with non-IVT. While, in post-2015, IVT administered within 2 h significantly reduced the 3-month, 1-year, 2-year, and 4-year mortality (p < 0.05). MT only reduced 1-year mortality pre-2015; however, MT significantly reduced the 3-month, 1-year, and 2-year mortality post-2015 (p < 0.05). Post-stroke antiplatelet and anticoagulant drugs significantly reduced the 3-month, 1-year, 2-year, and 4-year mortality post-2015. DiscussionSince 2015, faster IVT has significantly reduced the short- and long-term mortality in patients with AIS; MT reduced the 3-month, 1-year, and 2-year mortality. Post-stroke antithrombotic medication has significantly lowered the 2- and 4-year mortality since 2015. ConclusionsChanging trends in AIS management since 2015 have improved the prognosis of patients with AIS.
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College of Medicine > Department of Neurosurgery > 1. Journal Articles
Graduate School > Department of Integrated Biomedical Science > 1. Journal Articles

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