장미색 비강진에서 마크로라이드계 항생제와 위약의 치료 효과비교: 체계적 문헌고찰 및 메타분석The Effectiveness of Antibiotic Macrolides Compared to Placebo for the Treatment of Pityriasis Rosea: A Systematic Review and Meta-analysis
- Other Titles
- The Effectiveness of Antibiotic Macrolides Compared to Placebo for the Treatment of Pityriasis Rosea: A Systematic Review and Meta-analysis
- Authors
- 김우일; 허재영; 박태흠; 김수영; 조문균
- Issue Date
- 2021
- Publisher
- 대한피부과학회
- Keywords
- Azithromycin; Clarithromycin; Erythromycin; Macrolide; Pityriasis rosea
- Citation
- 대한피부과학회지, v.59, no.3, pp.181 - 187
- Journal Title
- 대한피부과학회지
- Volume
- 59
- Number
- 3
- Start Page
- 181
- End Page
- 187
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2146
- ISSN
- 0494-4739
- Abstract
- Background: Pityriasis rosea is a self-limiting, acute, or subacute inflammatory skin disease that usually starts with a herald patch on the trunk and progresses to a generalized rash over the trunk and limbs. Some clinical trials have suggested that antibiotic macrolides help shorten the duration of skin manifestations in pityriasis rosea; however, the extent of the benefits is unclear.
Objective: To evaluate the effectiveness of antibiotic macrolides compared to placebo in pityriasis rosea.
Methods: A computerized search was performed using different databases, including Cochrane, Embase, and PubMed. Five randomized controlled trials were included. Then, statistical analyses of the outcome data extracted from the studies were performed using Rex Software (version 3.0.1).
Results: Total 160 records were identified by searching databases including Cochrane, Embase, and PubMed. The results of the meta-analysis demonstrated statistical differences between the use of antibiotic macrolides and placebo in the complete and partial resolution of pityriasis rosea (effectiveness) (RR: 1.84, 95% CI: 1.21∼2.78, p=0.004).
However, in subgroup analyses, there were no statistical differences compared to placebo in the skin manifestation effectiveness group for azithromycin and clarithromycin, whereas erythromycin showed statistical differences.
Conclusion: Erythromycin was superior to placebo in the treatment of pityriasis rosea. However, this study had some limitations, including insufficient articles and data. Therefore, further investigation is required.
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Collections - College of Medicine > Department of Dermatology > 1. Journal Articles
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