Changes in the characteristics of community-onset fluoroquinolone-resistant Escherichia coli isolates causing community-acquired acute pyelonephritis in South Koreaopen access
- Authors
- Kim, Bongyoung; Kim, Jeoungyeon; Jo, Hyun-Uk; Kwon, Ki Tae; Ryu, Seong-Yeol; Wie, Seong-Heon; Kim, Jieun; Park, Se Yoon; Hong, Kyung-Wook; Kim, Hye In; Kim, Hyun Ah; Kim, Mi-Hee; Bae, Mi Hyun; Sohn, Yong-Hak; Kim, Jieun; Lee, Yangsoon; Pai, Hyunjoo
- Issue Date
- Aug-2022
- Publisher
- Elsevier Taiwan
- Keywords
- Urinary tract infection; Escherichia coli; Antimicrobial resistance; ST131; Korea
- Citation
- Journal of Microbiology, Immunology and Infection, v.55, no.4, pp 678 - 685
- Pages
- 8
- Journal Title
- Journal of Microbiology, Immunology and Infection
- Volume
- 55
- Number
- 4
- Start Page
- 678
- End Page
- 685
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21699
- DOI
- 10.1016/j.jmii.2022.01.001
- ISSN
- 1684-1182
1995-9133
- Abstract
- Purpose: This study aimed to examine the changes in the characteristics of community-onset fluoroquinolone-resist ant (FQ-R) Escherichia coli isolates causing community-acquired acute pyelonephritis (APN) in South Korea. Methods: Blood or urine samples were prospectively collected from patients aged > 15 years with community-acquired APN who were admitted to one of the eight Korean hospitals included in this study between September 2017 and August 2018. Phylogenetic typing, multi -locus sequence typing, and molecular characterization of 13-lactamase resistance and plasmid-mediated quinolone resistance (PMQR) determinants were performed. The data were compared with those from a previous study with the same design conducted in 2010-2011. Results: A total of 300 and 346 isolates were identified in 2010-2011 and 2017-2018, respec-tively. Among them, 76 (22.0%) and 77 (25.7%) FQ-R isolates were identified in 2010-2011 and 2017-2018, respectively. A significantly higher antimicrobial resistance against third-to fourth -generation cephalosporins, including cefotaxime (23.9% vs. 77.9%, P < 0.001), were observed among FQ-R isolates in 2017-2018 than among those in 2010-2011. A higher proportion of ST131 isolates (27.6% vs. 66.2%, P < 0.001), as well as isolates that had extended-spectrum 13-lactamase (ESBL)/plasmid-mediated AmpC 13-lactamase (PABL) (23.7% vs. 79.2%, P < 0.001), was observed in 2017-2018 than in 2010-2011. Further, more PMQR determinants (11.8% vs. 40.8%, P < 0.001) were observed in 2017-2018 than in 2010-2011. Conclusions: Among uropathogenic FQ-R E. coli isolates in South Korea, the prevalence of ST131 and the proportion of isolates containing ESBL and/or PMQR determinants have increased. Copyright 2022, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.
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