Genetic Variations miR-10aA > T, miR-30cA > G, miR-181aT > C, and miR-499bA > G and the Risk of Recurrent Pregnancy Loss in Korean Womenopen access
- Authors
- An, Hui-Jeong; Cho, Sung-Hwan; Park, Han-Sung; Kim, Ji-Hyang; Kim, Young-Ran; Lee, Woo-Sik; Lee, Jung-Ryeol; Joo, Seong-Soo; Ahn, Eun-Hee; Kim, Nam-Keun
- Issue Date
- Oct-2022
- Publisher
- MDPI AG
- Keywords
- recurrent pregnancy loss; single-nucleotide polymorphism (SNP); microRNA
- Citation
- Biomedicines, v.10, no.10
- Journal Title
- Biomedicines
- Volume
- 10
- Number
- 10
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21768
- DOI
- 10.3390/biomedicines10102395
- ISSN
- 2227-9059
- Abstract
- This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women. Blood samples were collected from 381 RPL patients and 281 control participants, and genotyping of miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G was carried out by TaqMan miRNA RT-Real Time polymerase chain reaction (PCR). Four polymorphisms were identified, including miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G. MiR-10a dominant model (AA vs. AT + TT) and miR-499bGG genotypes were associated with increased RPL risk (adjusted odds ratio [AOR] = 1.520, 95% confidence interval [CI] = 1.038-2.227, p = 0.032; AOR = 2.956, 95% CI = 1.168-7.482, p = 0.022, respectively). Additionally, both miR-499 dominant (AA vs. AG + GG) and recessive (AA + AG vs. GG) models were significantly associated with increased RPL risk (AOR = 1.465, 95% CI = 1.062-2.020, p = 0.020; AOR = 2.677, 95% CI = 1.066-6.725, p = 0.036, respectively). We further propose that miR-10aA>T, miR-30cA>G, and miR-499bA>G polymorphisms effects could contribute to RPL and should be considered during RPL patient evaluation.
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Collections - College of Medicine > Department of Anesthesiology > 1. Journal Articles
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