Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Autoantibodies in central nervous system and neuromuscular autoimmune disorders A narrative reviewopen access

Authors
Jeon, Mi YoungSeok, Jin MyoungFujihara, KazuoKim, Byoung Joon
Issue Date
Jun-2022
Publisher
SUNGKYUNKWAN UNIV SCH MEDICINE
Keywords
Autoantibodies; Multiple sclerosis; Myasthenia gravis; Neuromyelitis optica; Polyradiculoneuropathy, chronic inflammatory demyelinating
Citation
Precision and Future Medicine, v.6, no.2, pp 105 - 116
Pages
12
Journal Title
Precision and Future Medicine
Volume
6
Number
2
Start Page
105
End Page
116
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21825
DOI
10.23838/pfm.2021.00198
ISSN
2508-7940
Abstract
The discovery of novel autoantibodies in neurological disorders contributes to a better understanding of its pathogenesis, improves the accuracy of diagnosis, and leads to new treatment strategies. Advances in techniques for the screening and detection of autoantibodies have enabled the discovery of new antibodies in the central nervous system (CNS) and neuromuscular diseases. Cell-based assays using live or fixed cells overexpressing target antigens are widely used for autoantibody-based diagnosis in clinical practice. Common pathogenic autoantibodies are unknown in most patients with multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Novel pathogenic autoantibodies to aquaporin-4 and myelin oligodendrocyte glycoprotein (MOG) have been identified in neuromyelitis optica spectrum disorder and MOG antibody-associated disease, respectively. These diseases have clinical similarities to MS, but with the discovery of pathogenic autoantibodies, they are now recognized as distinct disease entities. Antibodies to paranodal membrane proteins such as neurofascin-155, contactin-1, contactin-associated protein-1 in CIDP and muscle-specific kinase and low-density lipoprotein receptor-related protein 4 in myasthenia gravis were added to the profiles of autoantibodies in neurological disorders. Despite the relatively low frequency of seropositivity, autoantibody detection is currently essential for the clinical diagnosis of CNS and neuromuscular autoimmune disorders, and differential approaches to seropositive patients will contribute to more personalized medicine. We reviewed recent discoveries of autoantibodies and their clinical implications in CNS and neuromuscular disorders.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Neurology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Seok, Jin Myoung photo

Seok, Jin Myoung
College of Medicine (Department of Neurology)
Read more

Altmetrics

Total Views & Downloads

BROWSE