Very severe immune aplastic anemia after mRNA vaccination against COVID-19 responds well to immunosuppressive therapy: clinical characteristics and comparison to previous reportsopen access
- Authors
- Woo, Suhyeon; Kim, Bohyun; Lee, Sang-Cheol; Kim, Min-Sun; Yoon, Young Ahn; Choi, Young-Jin
- Issue Date
- Dec-2022
- Publisher
- Maney Publishing
- Keywords
- Aplastic anemia; SARS-CoV-2; COVID-19; vaccine; immunosuppressive therapy
- Citation
- Hematology, v.27, no.1, pp 1191 - 1195
- Pages
- 5
- Journal Title
- Hematology
- Volume
- 27
- Number
- 1
- Start Page
- 1191
- End Page
- 1195
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21833
- DOI
- 10.1080/16078454.2022.2140986
- ISSN
- 1024-5332
1607-8454
- Abstract
- Objective Various hematologic side effects of the Coronavirus Disease 2019 (COVID-19) vaccination has been reported, and most of them are thought to be related to autoimmune pathways. To the best of our knowledge, only few cases of post-COVID-19 vaccination aplastic anemia (AA) have been reported and there is no reported Korean case of COVID-19 vaccine-induced AA yet. We present a case of severe immune-mediated AA that developed after the administration of a messenger ribonucleic acid (mRNA) gene-based spike protein vaccine against COVID-19, which responded well to immunosuppressive therapy, and discuss the probable pathogenesis of AA and the implication of vaccination along with a comparison of previous cases reported. Methods A 53-year-old Korean man developed sudden pancytopenia three months after COVID-19 vaccination. To evaluate the cause of pancytopenia, a bone marrow study was performed. Results A diagnosis of AA was made through the bone marrow study and he received triple immunosuppressive therapy (IST). After triple IST for five months, his blood cell count was improved and maintained without transfusion and his follow-up bone marrow examination showed improved cellularity. Conclusion COVID-19 vaccine might be associated with the development of immune-mediated AA. Prompt hematologic evaluation should be performed when there are symptoms or signs suggestive of cytopenia after COVID-19 vaccination. Although the clinical outcome of post-vaccination AA varies, a good prognosis can be possible for patients with COVID-19 vaccination-induced AA.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Clinical Pathology > 1. Journal Articles
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