Synaptic Remodeling of the Auditory Cortex Following Bilateral Blindness: Evidence of Cross-modal Plasticity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한재준 | - |
dc.contributor.author | 노태수 | - |
dc.contributor.author | Suh Myung-Whan | - |
dc.contributor.author | Kim Seung Ha | - |
dc.contributor.author | 김도희 | - |
dc.contributor.author | Kim Sang Jeong | - |
dc.contributor.author | Oh Seung-ha | - |
dc.date.accessioned | 2022-11-29T06:41:30Z | - |
dc.date.available | 2022-11-29T06:41:30Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 1226-2560 | - |
dc.identifier.issn | 2093-8144 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21867 | - |
dc.description.abstract | We aimed to evaluate structural dynamic changes of neurons in the auditory cortex after visual deprivation. We longitudinally tracked dendritic spines for 3 weeks after visual deprivation in vivo using a two-photon microscope. GFP-labeled dendritic spines in the auditory cortex were serially followed after bilateral enucleation. The turnover rate, density, and size of the spines in the dendrites were evaluated 1, 2, and 3 weeks after visual deprivation. The turnover rate of the dendritic spines in the auditory cortex increased at 1 week (20.1±7.3%) after bilateral enucleation compared to baseline (12.5±7.9%); the increase persisted for up to 3 weeks (20.9±11.0%). The spine loss rate was slightly higher than the spine gain rate. The average spine density (number of spines per 1 μm of dendrite) was significantly lower at 2 weeks (2W; 0.22±0.06 1/μm) and 3 W (0.22±0.08 1/μm) post-nucleation compared to baseline (0.026±0.09 1/μm). We evaluated the change of synaptic strength in the stable spines at each time point. The normalized spine size in the auditory cortex was significantly increased after bilateral blindness at 1 W postoperatively (1.36±0.92), 2 W postoperatively (1.40±1.18), and 3 W postoperatively (1.36±0.88) compared to baseline. Sensory deprivation resulted in remodeling of the neural circuitry in the spared cortex, via cross-modal plasticity in the direction of partial breakdown of synapses, and enhanced strength of the remaining synapses. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국뇌신경과학회 | - |
dc.title | Synaptic Remodeling of the Auditory Cortex Following Bilateral Blindness: Evidence of Cross-modal Plasticity | - |
dc.title.alternative | Synaptic Remodeling of the Auditory Cortex Following Bilateral Blindness: Evidence of Cross-modal Plasticity | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5607/en22020 | - |
dc.identifier.scopusid | 2-s2.0-85143867423 | - |
dc.identifier.wosid | 000903744000003 | - |
dc.identifier.bibliographicCitation | Experimental Neurobiology, v.31, no.5, pp 299 - 306 | - |
dc.citation.title | Experimental Neurobiology | - |
dc.citation.volume | 31 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 299 | - |
dc.citation.endPage | 306 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002895490 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | SINGLE-SIDED DEAFNESS | - |
dc.subject.keywordPlus | VISUAL-CORTEX | - |
dc.subject.keywordPlus | CORTICES | - |
dc.subject.keywordAuthor | Auditory cortex | - |
dc.subject.keywordAuthor | Cross-modal plasticity | - |
dc.subject.keywordAuthor | Two-photon | - |
dc.subject.keywordAuthor | Sensory deprivation | - |
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