Synaptic Remodeling of the Auditory Cortex Following Bilateral Blindness: Evidence of Cross-modal PlasticitySynaptic Remodeling of the Auditory Cortex Following Bilateral Blindness: Evidence of Cross-modal Plasticity
- Other Titles
- Synaptic Remodeling of the Auditory Cortex Following Bilateral Blindness: Evidence of Cross-modal Plasticity
- Authors
- 한재준; 노태수; Suh Myung-Whan; Kim Seung Ha; 김도희; Kim Sang Jeong; Oh Seung-ha
- Issue Date
- Oct-2022
- Publisher
- 한국뇌신경과학회
- Keywords
- Auditory cortex; Cross-modal plasticity; Two-photon; Sensory deprivation
- Citation
- Experimental Neurobiology, v.31, no.5, pp 299 - 306
- Pages
- 8
- Journal Title
- Experimental Neurobiology
- Volume
- 31
- Number
- 5
- Start Page
- 299
- End Page
- 306
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21867
- DOI
- 10.5607/en22020
- ISSN
- 1226-2560
2093-8144
- Abstract
- We aimed to evaluate structural dynamic changes of neurons in the auditory cortex after visual deprivation. We longitudinally tracked dendritic spines for 3 weeks after visual deprivation in vivo using a two-photon microscope. GFP-labeled dendritic spines in the auditory cortex were serially followed after bilateral enucleation. The turnover rate, density, and size of the spines in the dendrites were evaluated 1, 2, and 3 weeks after visual deprivation. The turnover rate of the dendritic spines in the auditory cortex increased at 1 week (20.1±7.3%) after bilateral enucleation compared to baseline (12.5±7.9%); the increase persisted for up to 3 weeks (20.9±11.0%). The spine loss rate was slightly higher than the spine gain rate. The average spine density (number of spines per 1 μm of dendrite) was significantly lower at 2 weeks (2W; 0.22±0.06 1/μm) and 3 W (0.22±0.08 1/μm) post-nucleation compared to baseline (0.026±0.09 1/μm). We evaluated the change of synaptic strength in the stable spines at each time point. The normalized spine size in the auditory cortex was significantly increased after bilateral blindness at 1 W postoperatively (1.36±0.92), 2 W postoperatively (1.40±1.18), and 3 W postoperatively (1.36±0.88) compared to baseline. Sensory deprivation resulted in remodeling of the neural circuitry in the spared cortex, via cross-modal plasticity in the direction of partial breakdown of synapses, and enhanced strength of the remaining synapses.
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Collections - College of Medicine > Department of Otorhinolaryngology > 1. Journal Articles
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