The Urinary Microbiome; Axis Crosstalk and Short-Chain Fatty Acidopen access
- Authors
- Yang, Hee Jo; Kim, Doo Sang; Lee, Kwang Woo; Kim, Young Ho
- Issue Date
- Dec-2022
- Publisher
- MDPI AG
- Keywords
- microbiota; brain-gut axis; inflammasomes; fatty acids
- Citation
- Diagnostics, v.12, no.12
- Journal Title
- Diagnostics
- Volume
- 12
- Number
- 12
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21988
- DOI
- 10.3390/diagnostics12123119
- ISSN
- 2075-4418
- Abstract
- Our knowledge that "urine is sterile" is no longer accepted after the development of a next-generation sequencing (NGS) test. Using NGS, microbiota in the human body were discovered, and it is expected that this will improve our understanding of human diseases. However, the mechanism involved in the effect of the microbiome on diseases is still poorly understood. Associations of gut microbiome with diseases have been recently reported. Based on such associations, bladder-gut-brain axis, gut-bladder axis, gut-vagina-bladder axis, and gut-kidney axis as novel mechanisms of action of the microbiome have been suggested. Each axis can influence the development and progression of disease through interactions. In these interactions, metabolites of the microbiome including short-chain fatty acids (SCFA) and the inflammasome play an important role. Inflammasomes are multiprotein oligomers that can initiate inflammatory responses. Inflammasomes can trigger inflammation and pyroptosis and ultimately contribute to disease development. SCFAs play an important role in immune cell migration, cytokine production, and maintenance of cellular homeostasis. Associations of inflammasomes with systemic diseases such as obesity and insulin resistance have been reported. The roles of inflammasomes and SCFAs in kidney, bladder, and prostate diseases have also been revealed recently.
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- Appears in
Collections - College of Medicine > Department of Urology > 1. Journal Articles
- College of Medicine > Department fo Urology > 1. Journal Articles
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