Hemispherically lateralized rhythmic oscillations in the cingulate-amygdala circuit drive affective empathy in mice
DC Field | Value | Language |
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dc.contributor.author | Kim, Seong-Wook | - |
dc.contributor.author | Kim, Minsoo | - |
dc.contributor.author | Baek, Jinhee | - |
dc.contributor.author | Latchoumane, Charles-Francois | - |
dc.contributor.author | Gangadharan, Gireesh | - |
dc.contributor.author | Yoon, Yongwoo | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.contributor.author | Lee, Jin Hyung | - |
dc.contributor.author | Shin, Hee-Sup | - |
dc.date.accessioned | 2023-03-09T08:40:35Z | - |
dc.date.available | 2023-03-09T08:40:35Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.issn | 1097-4199 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22191 | - |
dc.description.abstract | Observational fear, a form of emotional contagion, is thought to be a basic form of affective empathy. How-ever, the neural process engaged at the specific moment when socially acquired information provokes an emotional response remains elusive. Here, we show that reciprocal projections between the anterior cingu-late cortex (ACC) and basolateral amygdala (BLA) in the right hemisphere are essential for observational fear, and 5-7 Hz neural oscillations were selectively increased in those areas at the onset of observational freezing. A closed-loop disruption demonstrated the causal relationship between 5-7 Hz oscillations in the cingulo-amygdala circuit and observational fear responses. The increase/decrease in theta power induced by opto-genetic manipulation of the hippocampal theta rhythm bi-directionally modulated observational fear. Together, these results indicate that hippocampus-dependent 5-7 Hz oscillations in the cingulo-amygdala circuit in the right hemisphere are the essential component of the cognitive process that drives empathic fear, but not freezing, in general. | - |
dc.publisher | Cell Press | - |
dc.title | Hemispherically lateralized rhythmic oscillations in the cingulate-amygdala circuit drive affective empathy in mice | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.neuron.2022.11.001 | - |
dc.identifier.scopusid | 2-s2.0-85147190449 | - |
dc.identifier.wosid | 000968743200001 | - |
dc.identifier.bibliographicCitation | Neuron, v.111, no.3, pp 418 - 429.e4 | - |
dc.citation.title | Neuron | - |
dc.citation.volume | 111 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 418 | - |
dc.citation.endPage | 429.e4 | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | MEDIAL PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | THETA-RHYTHM | - |
dc.subject.keywordPlus | VENTRAL HIPPOCAMPUS | - |
dc.subject.keywordPlus | FEAR | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | EXTINCTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PAIN | - |
dc.subject.keywordPlus | SYNCHRONIZE | - |
dc.subject.keywordPlus | CORTICES | - |
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