Hemispherically lateralized rhythmic oscillations in the cingulate-amygdala circuit drive affective empathy in mice
- Authors
- Kim, Seong-Wook; Kim, Minsoo; Baek, Jinhee; Latchoumane, Charles-Francois; Gangadharan, Gireesh; Yoon, Yongwoo; Kim, Duk-Soo; Lee, Jin Hyung; Shin, Hee-Sup
- Issue Date
- Feb-2023
- Publisher
- Cell Press
- Citation
- Neuron, v.111, no.3, pp 418 - 429.e4
- Journal Title
- Neuron
- Volume
- 111
- Number
- 3
- Start Page
- 418
- End Page
- 429.e4
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22191
- DOI
- 10.1016/j.neuron.2022.11.001
- ISSN
- 0896-6273
1097-4199
- Abstract
- Observational fear, a form of emotional contagion, is thought to be a basic form of affective empathy. How-ever, the neural process engaged at the specific moment when socially acquired information provokes an emotional response remains elusive. Here, we show that reciprocal projections between the anterior cingu-late cortex (ACC) and basolateral amygdala (BLA) in the right hemisphere are essential for observational fear, and 5-7 Hz neural oscillations were selectively increased in those areas at the onset of observational freezing. A closed-loop disruption demonstrated the causal relationship between 5-7 Hz oscillations in the cingulo-amygdala circuit and observational fear responses. The increase/decrease in theta power induced by opto-genetic manipulation of the hippocampal theta rhythm bi-directionally modulated observational fear. Together, these results indicate that hippocampus-dependent 5-7 Hz oscillations in the cingulo-amygdala circuit in the right hemisphere are the essential component of the cognitive process that drives empathic fear, but not freezing, in general.
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Collections - College of Medicine > Department of Anatomy > 1. Journal Articles
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