Subclinical thyroid dysfunction and chronic kidney disease: a nationwide population-based studyopen access
- Authors
- Kim, Hye Jeong; Park, Sang Joon; Park, Hyeong Kyu; Byun, Dong Won; Suh, Kyoil; Yoo, Myung Hi
- Issue Date
- Mar-2023
- Publisher
- BioMed Central
- Keywords
- Thyroid function; Hypothyroidism; Chronic kidney disease; KNHANES
- Citation
- BMC Nephrology, v.24, no.1
- Journal Title
- BMC Nephrology
- Volume
- 24
- Number
- 1
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22395
- DOI
- 10.1186/s12882-023-03111-7
- ISSN
- 1471-2369
1471-2369
- Abstract
- BackgroundChronic kidney disease (CKD) has a significant impact on global health. Studies have shown that subclinical thyroid dysfunction may be related to CKD, but the association between subclinical thyroid dysfunction and CKD in the general population is unclear. We aimed to evaluate the risk of CKD according to thyroid function status in a large cohort.MethodsWe analyzed data from a nationwide, population-based, cross-sectional survey (KNHANES VI). A total of 3,257 participants aged >= 19 years who underwent thyroid and kidney function assessments were included in this study. CKD was defined as an estimated glomerular filtration rate < 60 mL/min/1.73 m(2) and/or urine albumin-creatinine ratio >= 30 mg/g. The risk of CKD according to thyroid function status was assessed using logistic regression, adjusted for potential confounders.ResultsOverall, 6.7% of the participants had CKD. There were no significant differences in thyroid-stimulating hormone and free thyroxine levels between the groups with and without CKD. The proportion of participants with CKD was significantly different among the thyroid function status groups (p = 0.012) and tended to increase significantly in the following order: subclinical hyperthyroidism (1.5%), euthyroidism (6.6%), and subclinical hypothyroidism (12.6%) (p for trend < 0.001). Subclinical hypothyroidism was a significant risk factor for CKD, even after adjusting for sex, age, household income, education, smoking, alcohol consumption, walking activity, abdominal obesity, hypertension, low high-density lipoprotein cholesterol, elevated triglycerides, hyperglycemia, free thyroxine, and thyroid-peroxidase anibody (odds ratio 2.161, 95% confidence interval 1.032-4.527, p = 0.041).ConclusionSubclinical hypothyroidism is an independent predictor of CKD in the general population.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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