Lung function trajectory of rheumatoid arthritis-associated interstitial lung disease
DC Field | Value | Language |
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dc.contributor.author | Chang, Sung Hae | - |
dc.contributor.author | Lee, Ji Sung | - |
dc.contributor.author | Ha, You-Jung | - |
dc.contributor.author | Kim, Min Uk | - |
dc.contributor.author | Park, Chan Ho | - |
dc.contributor.author | Lee, Jeong Seok | - |
dc.contributor.author | Kim, Ji-Won | - |
dc.contributor.author | Chung, Sang Wan | - |
dc.contributor.author | Pyo, Jung Yoon | - |
dc.contributor.author | Lee, Sung Won | - |
dc.contributor.author | Kang, Eun Ha | - |
dc.contributor.author | Lee, Yeon-Ah | - |
dc.contributor.author | Park, Yong-Beom | - |
dc.contributor.author | Choe, Jung-Yoon | - |
dc.contributor.author | Lee, Eun Young | - |
dc.date.accessioned | 2023-05-25T01:41:17Z | - |
dc.date.available | 2023-05-25T01:41:17Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1462-0324 | - |
dc.identifier.issn | 1462-0332 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22441 | - |
dc.description.abstract | Objectives To explore the course of lung function and RA disease activity and predictive factors for deteriorating lung function in patients with RA-interstitial lung disease (ILD). Methods The Korean Rheumatoid Arthritis-Interstitial Lung Disease cohort is a multicentre, prospective observational cohort. Patients with RA-ILD were enrolled and followed up annually for 3 years for RA disease activity and ILD status assessment. Group-based modelling was used to cluster a similar predicted percentage of forced vital capacity (FVC%) patterns into trajectories. Results This study included 140 patients who underwent at least two pulmonary function tests. Four distinctive trajectories for predicted FVC% were 'improving' [n = 11 (7.9%)], 'stable' [n = 68 (38.4%)], 'slowly declining' [n = 54 (48.6%)] and 'rapidly declining' [n = 7 (5.0%)]. Most (77.7%) patients maintained or improved to low RA disease activity. The lung function trajectory was not comparable to the RA disease activity trajectory. Age >= 70 years [relative risk (RR) 10.8 (95% CI 1.30, 89.71)] and early RA diagnosed within the preceding 2 years [RR 10.1 (95% CI 1.22, 84.2)] were associated with increased risk for rapidly declining predicted FVC%. The risk for deterioration or mortality increased in patients with a simultaneous diagnosis of RA and ILD within 24 weeks [RR 9.18 (95% CI 2.05, 41.0)] and the extent of lung involvement [RR 3.28 (95% CI 1.12, 9.60)]. Conclusion Most patients with RA-ILD experienced stable or slowly declining lung function. In 5% of patients, predicted FVC% deteriorated rapidly, especially in older adults with early RA. The lung function trajectory was not comparable to the RA disease activity trajectory. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Oxford University Press | - |
dc.title | Lung function trajectory of rheumatoid arthritis-associated interstitial lung disease | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1093/rheumatology/kead027 | - |
dc.identifier.scopusid | 2-s2.0-85152005283 | - |
dc.identifier.wosid | 000929188400001 | - |
dc.identifier.bibliographicCitation | Rheumatology, v.62, no.9, pp 3014 - 3024 | - |
dc.citation.title | Rheumatology | - |
dc.citation.volume | 62 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 3014 | - |
dc.citation.endPage | 3024 | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | IDIOPATHIC PULMONARY-FIBROSIS | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | PREDICTORS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | COHORT | - |
dc.subject.keywordAuthor | RA | - |
dc.subject.keywordAuthor | interstitial lung disease | - |
dc.subject.keywordAuthor | lung function trajectory | - |
dc.subject.keywordAuthor | prospective cohort study | - |
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