Lung function trajectory of rheumatoid arthritis-associated interstitial lung disease
- Authors
- Chang, Sung Hae; Lee, Ji Sung; Ha, You-Jung; Kim, Min Uk; Park, Chan Ho; Lee, Jeong Seok; Kim, Ji-Won; Chung, Sang Wan; Pyo, Jung Yoon; Lee, Sung Won; Kang, Eun Ha; Lee, Yeon-Ah; Park, Yong-Beom; Choe, Jung-Yoon; Lee, Eun Young
- Issue Date
- Sep-2023
- Publisher
- Oxford University Press
- Keywords
- RA; interstitial lung disease; lung function trajectory; prospective cohort study
- Citation
- Rheumatology, v.62, no.9, pp 3014 - 3024
- Pages
- 11
- Journal Title
- Rheumatology
- Volume
- 62
- Number
- 9
- Start Page
- 3014
- End Page
- 3024
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22441
- DOI
- 10.1093/rheumatology/kead027
- ISSN
- 1462-0324
1462-0332
- Abstract
- Objectives To explore the course of lung function and RA disease activity and predictive factors for deteriorating lung function in patients with RA-interstitial lung disease (ILD). Methods The Korean Rheumatoid Arthritis-Interstitial Lung Disease cohort is a multicentre, prospective observational cohort. Patients with RA-ILD were enrolled and followed up annually for 3 years for RA disease activity and ILD status assessment. Group-based modelling was used to cluster a similar predicted percentage of forced vital capacity (FVC%) patterns into trajectories. Results This study included 140 patients who underwent at least two pulmonary function tests. Four distinctive trajectories for predicted FVC% were 'improving' [n = 11 (7.9%)], 'stable' [n = 68 (38.4%)], 'slowly declining' [n = 54 (48.6%)] and 'rapidly declining' [n = 7 (5.0%)]. Most (77.7%) patients maintained or improved to low RA disease activity. The lung function trajectory was not comparable to the RA disease activity trajectory. Age >= 70 years [relative risk (RR) 10.8 (95% CI 1.30, 89.71)] and early RA diagnosed within the preceding 2 years [RR 10.1 (95% CI 1.22, 84.2)] were associated with increased risk for rapidly declining predicted FVC%. The risk for deterioration or mortality increased in patients with a simultaneous diagnosis of RA and ILD within 24 weeks [RR 9.18 (95% CI 2.05, 41.0)] and the extent of lung involvement [RR 3.28 (95% CI 1.12, 9.60)]. Conclusion Most patients with RA-ILD experienced stable or slowly declining lung function. In 5% of patients, predicted FVC% deteriorated rapidly, especially in older adults with early RA. The lung function trajectory was not comparable to the RA disease activity trajectory.
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Collections - College of Medicine > Department of Radiology > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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